Reactome | Activated MAPKs phosphorylate MAP2K1

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Activated MAPKs phosphorylate MAP2K1 Show undefined attributes

authored	[InstanceEdit:5674393] Rothfels, Karen, 2015-02-11
catalystActivity	[CatalystActivity:5674493] protein serine/threonine kinase activity of p-T,Y MAPK monomers and dimers [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5674495] Rothfels, Karen, 2015-02-12
dbId	5674496
displayName	Activated MAPKs phosphorylate MAP2K1
edited	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
eventOf	[Pathway:R-HSA-5674499] Negative feedback regulation of MAPK pathway - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-5672705] p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5673933] A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal [LiteratureReference:197555] Growth factor-stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1) [LiteratureReference:5674478] The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Activated MAPKs phosphorylate MAP2K1
orthologousEvent	[Reaction:R-DDI-5674496] Activated MAPKs phosphorylate MAP2K1 - Dictyostelium discoideum [Reaction:R-CEL-5674496] Activated MAPKs phosphorylate MAP2K1 - Caenorhabditis elegans [Reaction:R-DME-5674496] Activated MAPKs phosphorylate MAP2K1 - Drosophila melanogaster [Reaction:R-DRE-5674496] Activated MAPKs phosphorylate MAP2K1 - Danio rerio [Reaction:R-RNO-5674496] Activated MAPKs phosphorylate MAP2K1 - Rattus norvegicus [Reaction:R-MMU-5674496] Activated MAPKs phosphorylate MAP2K1 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-5674489] p-2S,T MAP2K1:p-2S MAPK2K2 heterodimer [cytosol]
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5674496
summation	[Summation:5674494] Activated MAPK proteins negatively regulate MAP2K1:MAP2K2 he...

Referrals

(hasEvent)

[Pathway:R-HSA-5674499] Negative feedback regulation of MAPK pathway