Reactome | EGFRvIII cancer variant does not bind EGF ligand

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EGFRvIII cancer variant does not bind EGF ligand Show undefined attributes

authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5638134] Orlic-Milacic, Marija, 2014-11-13
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	5638137
disease	[Disease:1500689] cancer
displayName	EGFRvIII cancer variant does not bind EGF ligand
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990852] Gillespie, ME, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:5638136] loss_of_function of EGFRvIII mutant:HSP90:CDC37 [plasma membrane]
eventOf	[Pathway:R-HSA-5637810] Constitutive Signaling by EGFRvIII - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-179863] EGF [extracellular region] [Complex:R-HSA-1248004] EGFRvIII mutant:HSP90:CDC37 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2008185] Glycosylation-induced conformational modification positively regulates receptor-receptor association: a study with an aberrant epidermal growth factor receptor (EGFRvIII/DeltaEGFR) expressed in cancer cells
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EGFRvIII cancer variant does not bind EGF ligand
normalReaction	[Reaction:R-HSA-177942] EGFR binds EGF ligand
precedingEvent	[Reaction:R-HSA-1247999] EGFRvIII mutant binds chaperone proteins HSP90 and CDC37 - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5638137
summation	[Summation:5638135] EGFRvIII mutant lacks the ligand binding domain and is there...

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(hasEvent)

[Pathway:R-HSA-5637810] Constitutive Signaling by EGFRvIII

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