Reactome | Ligand-independent dimerization of EGFRvIII mutant

Schema > Reaction > Entries

Ligand-independent dimerization of EGFRvIII mutant Show undefined attributes

authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1247996] Orlic-Milacic, Marija, 2011-04-08
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	1248002
disease	[Disease:1500689] cancer
displayName	Ligand-independent dimerization of EGFRvIII mutant
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:9630155] gain_of_function of EGFRvIII mutant:HSP90:CDC37 [plasma membrane]
eventOf	[Pathway:R-HSA-5637810] Constitutive Signaling by EGFRvIII - Homo sapiens
followingEvent	[Reaction:R-HSA-1248655] Trans-autophosphorylation of EGFRvIII mutant dimers - Homo sapiens
input	2 × [Complex:R-HSA-1248004] EGFRvIII mutant:HSP90:CDC37 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2008185] Glycosylation-induced conformational modification positively regulates receptor-receptor association: a study with an aberrant epidermal growth factor receptor (EGFRvIII/DeltaEGFR) expressed in cancer cells
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ligand-independent dimerization of EGFRvIII mutant
output	[Complex:R-HSA-1248010] EGFRvIII mutant dimer [plasma membrane]
precedingEvent	[Reaction:R-HSA-1247999] EGFRvIII mutant binds chaperone proteins HSP90 and CDC37 - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1248002
summation	[Summation:1248014] EGFRvIII mutant lacks the ligand binding domain and is there...

Referrals

(hasEvent)	[Pathway:R-HSA-5637810] Constitutive Signaling by EGFRvIII
(precedingEvent)	[Reaction:R-HSA-1248655] Trans-autophosphorylation of EGFRvIII mutant dimers

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