Reactome | Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant

Schema > Reaction > Entries

Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant Show undefined attributes

authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
catalystActivity	[CatalystActivity:5637709] protein tyrosine kinase activity of p-5Y-EGFRvIII:PLCG1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5637797] Orlic-Milacic, Marija, 2014-11-12
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	5637795
disease	[Disease:1500689] cancer
displayName	Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:9630162] gain_of_function of p-5Y-EGFRvIII:PLCG1 [plasma membrane]
eventOf	[Pathway:R-HSA-5637810] Constitutive Signaling by EGFRvIII - Homo sapiens
followingEvent	[Reaction:R-HSA-5637800] Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-5637698] p-5Y-EGFRvIII:PLCG1 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:212708] Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro [LiteratureReference:212704] Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant
normalReaction	[Reaction:R-HSA-212710] EGFR activates PLC-gamma1 by phosphorylation
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-5637706] p-5Y-EGFRvIII:p-Y771,Y783,Y1254-PLCG1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-5637792] PLC-gamma 1 binds to p-EGFRvIII mutant - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5637795
summation	[Summation:5637780] Once recruited, PLC-gamma 1 is assumed to be phosphorylated ...

Referrals

(precedingEvent)	[Reaction:R-HSA-5637800] Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant
(hasEvent)	[Pathway:R-HSA-5637810] Constitutive Signaling by EGFRvIII

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