Reactome | PLC-gamma 1 binds to p-EGFRvIII mutant

Schema > Reaction > Entries

PLC-gamma 1 binds to p-EGFRvIII mutant Show undefined attributes

authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5637793] Orlic-Milacic, Marija, 2014-11-12
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	5637792
disease	[Disease:1500689] cancer
displayName	PLC-gamma 1 binds to p-EGFRvIII mutant
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:5638131] gain_of_function of p-5Y-EGFRvIII mutant dimer [plasma membrane]
eventOf	[Pathway:R-HSA-5637810] Constitutive Signaling by EGFRvIII - Homo sapiens
followingEvent	[Reaction:R-HSA-5637795] Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant - Homo sapiens
input	[Complex:R-HSA-1248654] p-5Y-EGFRvIII mutant dimer [plasma membrane] [EntityWithAccessionedSequence:R-HSA-167682] PLCG1 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2008120] EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PLC-gamma 1 binds to p-EGFRvIII mutant
normalReaction	[Reaction:R-HSA-212706] Phospholipase C-gamma1 binds to the activated EGF receptor
output	[Complex:R-HSA-5637698] p-5Y-EGFRvIII:PLCG1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-1248655] Trans-autophosphorylation of EGFRvIII mutant dimers - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5637792
summation	[Summation:5637771] Tyrosine residue Y992 (corresponding to Y1016 when counting ...

Referrals

(hasEvent)	[Pathway:R-HSA-5637810] Constitutive Signaling by EGFRvIII
(precedingEvent)	[Reaction:R-HSA-5637795] Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant

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