Reactome | Trans-autophosphorylation of EGFRvIII mutant dimers

authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
catalystActivity	[CatalystActivity:1248647] protein tyrosine kinase activity of EGFRvIII mutant dimer [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1248656] Orlic-Milacic, Marija, 2011-04-11
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	1248655
disease	[Disease:1500689] cancer
displayName	Trans-autophosphorylation of EGFRvIII mutant dimers
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:5638088] gain_of_function of EGFRvIII mutant dimer [plasma membrane]
eventOf	[Pathway:R-HSA-5637810] Constitutive Signaling by EGFRvIII - Homo sapiens
followingEvent	[Reaction:R-HSA-5637770] Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII - Homo sapiens [Reaction:R-HSA-5637792] PLC-gamma 1 binds to p-EGFRvIII mutant - Homo sapiens [FailedReaction:R-HSA-5637794] EGFRvIII does not bind CBL - Homo sapiens [Reaction:R-HSA-5637764] Binding of GRB2:GAB1 complex to p-EGFRvIII mutant - Homo sapiens [Reaction:R-HSA-5637766] Binding of SHC1 to p-5Y-EGFRvIII - Homo sapiens [Reaction:R-HSA-1247841] PLCG1 binds to ligand-responsive p-6Y-EGFR mutants - Homo sapiens [Reaction:R-HSA-1226016] Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants - Homo sapiens [Reaction:R-HSA-1225950] Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants - Homo sapiens [Reaction:R-HSA-1225947] Binding of SHC1 to p-6Y-EGFR mutants - Homo sapiens
input	10 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-1248010] EGFRvIII mutant dimer [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1248637] Hypophosphorylation of residue Y1045 leads to defective downregulation of EGFRvIII [LiteratureReference:1248643] Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Trans-autophosphorylation of EGFRvIII mutant dimers
normalReaction	[Reaction:R-HSA-177934] EGFR autophosphorylation
output	10 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-1248654] p-5Y-EGFRvIII mutant dimer [plasma membrane]
precedingEvent	[Reaction:R-HSA-1248002] Ligand-independent dimerization of EGFRvIII mutant - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1248655
summation	[Summation:1248645] Upon dimerization, EGFRvIII mutants trans-autophosphorylate ...
updateTrackers	[UpdateTracker:9846717] Update Tracker - [Reaction:1248655] Trans-autophosphorylation of EGFRvIII mutant dimers - v84:[modifyText]

(updatedInstance)	[UpdateTracker:9846717] Update Tracker - [Reaction:1248655] Trans-autophosphorylation of EGFRvIII mutant dimers - v84:[modifyText]
(hasEvent)	[Pathway:R-HSA-5637810] Constitutive Signaling by EGFRvIII
(precedingEvent)	[Reaction:R-HSA-5637770] Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII [Reaction:R-HSA-5637792] PLC-gamma 1 binds to p-EGFRvIII mutant [FailedReaction:R-HSA-5637794] EGFRvIII does not bind CBL [Reaction:R-HSA-5637764] Binding of GRB2:GAB1 complex to p-EGFRvIII mutant [Reaction:R-HSA-5637766] Binding of SHC1 to p-5Y-EGFRvIII [Reaction:R-HSA-1247841] PLCG1 binds to ligand-responsive p-6Y-EGFR mutants [Reaction:R-HSA-1226016] Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants [Reaction:R-HSA-1225950] Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants [Reaction:R-HSA-1225947] Binding of SHC1 to p-6Y-EGFR mutants

Trans-autophosphorylation of EGFRvIII mutant dimers Show undefined attributes

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