Reactome | Hedgehog 'off' state

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Hedgehog 'off' state Show undefined attributes

authored	[InstanceEdit:5422974] Rothfels, Karen, 2014-05-07
created	[InstanceEdit:5610786] Rothfels, Karen, 2014-07-22
dbId	5610787
displayName	Hedgehog 'off' state
doi	10.3180/REACT_267634.1
edited	[InstanceEdit:5617330] Gillespie, Marc E, 2014-07-25
eventOf	[Pathway:R-HSA-5358351] Signaling by Hedgehog - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-5610763] PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal - Homo sapiens [Reaction:R-HSA-5610723] GLI proteins bind SUFU - Homo sapiens [Reaction:R-HSA-5610733] KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules - Homo sapiens [BlackBoxEvent:R-HSA-5610767] The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip - Homo sapiens [BlackBoxEvent:R-HSA-5610766] The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base - Homo sapiens [Reaction:R-HSA-5610726] The IFT-A complex recruits TULP3 - Homo sapiens [Reaction:R-HSA-5610725] TULP3 is required for GPR161 localization in the cilium - Homo sapiens [Reaction:R-HSA-5610727] GPR161 promotes cAMP production in a G alpha(s)-dependent manner - Homo sapiens [Reaction:R-HSA-5610749] cAMP dissociates PKA, promoting GLI processing - Homo sapiens [Pathway:R-HSA-5610785] GLI3 is processed to GLI3R by the proteasome - Homo sapiens [BlackBoxEvent:R-HSA-5610752] GLI3R translocates to the nucleus - Homo sapiens [Reaction:R-HSA-5612508] GLI3R binds the PTCH1 promoter - Homo sapiens [BlackBoxEvent:R-HSA-5612510] Expression of PTCH1 is repressed by GLI3R in the absence of Hh signaling - Homo sapiens [Reaction:R-HSA-5617408] GLI3R binds the GLI1 promoter - Homo sapiens [BlackBoxEvent:R-HSA-5617412] Expression of GLI1 is repressed by GLI3R in the absence of Hh signaling - Homo sapiens [Reaction:R-HSA-5617410] GLI3R binds the GLI2 promoter - Homo sapiens [BlackBoxEvent:R-HSA-5617413] Expression of GLI2 is repressed by GLI3R in the absence of Hh signaling - Homo sapiens [Pathway:R-HSA-5610783] Degradation of GLI2 by the proteasome - Homo sapiens [Pathway:R-HSA-5610780] Degradation of GLI1 by the proteasome - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2014-12-08
literatureReference	[LiteratureReference:5627256] Mechanisms and functions of Hedgehog signalling across the metazoa [LiteratureReference:5358220] Gli proteins in development and disease [LiteratureReference:5609878] The primary cilium: a signalling centre during vertebrate development [LiteratureReference:5358245] The mechanisms of Hedgehog signalling and its roles in development and disease
maxDepth	3
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Hedgehog 'off' state
orthologousEvent	[Pathway:R-DME-5610787] Hedgehog 'off' state - Drosophila melanogaster [Pathway:R-PFA-5610787] Hedgehog 'off' state - Plasmodium falciparum [Pathway:R-SCE-5610787] Hedgehog 'off' state - Saccharomyces cerevisiae [Pathway:R-SPO-5610787] Hedgehog 'off' state - Schizosaccharomyces pombe [Pathway:R-DDI-5610787] Hedgehog 'off' state - Dictyostelium discoideum [Pathway:R-CEL-5610787] Hedgehog 'off' state - Caenorhabditis elegans [Pathway:R-GGA-5610787] Hedgehog 'off' state - Gallus gallus [Pathway:R-XTR-5610787] Hedgehog 'off' state - Xenopus tropicalis [Pathway:R-DRE-5610787] Hedgehog 'off' state - Danio rerio [Pathway:R-SSC-5610787] Hedgehog 'off' state - Sus scrofa [Pathway:R-BTA-5610787] Hedgehog 'off' state - Bos taurus [Pathway:R-CFA-5610787] Hedgehog 'off' state - Canis familiaris [Pathway:R-RNO-5610787] Hedgehog 'off' state - Rattus norvegicus [Pathway:R-MMU-5610787] Hedgehog 'off' state - Mus musculus
releaseDate	2014-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5617331] Liu, Yulu Cherry, 2014-08-01
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5610787
summation	[Summation:5610668] Hedgehog is a secreted morphogen that has evolutionarily con...
updateTrackers	[UpdateTracker:9785564] Update Tracker - [Pathway:5610787] Hedgehog 'off' state - v51:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9785564] Update Tracker - [Pathway:5610787] Hedgehog 'off' state - v51:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-5358351] Signaling by Hedgehog
(hasEncapsulatedEvent)	[Pathway:R-HSA-8878166] Transcriptional regulation by RUNX2

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