Reactome | Hedgehog 'off' state

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Hedgehog 'off' state Show undefined attributes

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10445500
displayName	Hedgehog 'off' state
eventOf	[Pathway:R-BTA-5358351] Signaling by Hedgehog - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-BTA-5610763] PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal - Bos taurus [Reaction:R-BTA-5610723] GLI proteins bind SUFU - Bos taurus [BlackBoxEvent:R-BTA-5610767] The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip - Bos taurus [BlackBoxEvent:R-BTA-5610766] The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base - Bos taurus [Reaction:R-BTA-5610726] The IFT-A complex recruits TULP3 - Bos taurus [Reaction:R-BTA-5610725] TULP3 is required for GPR161 localization in the cilium - Bos taurus [Reaction:R-BTA-5610727] GPR161 promotes cAMP production in a G alpha(s)-dependent manner - Bos taurus [Reaction:R-BTA-5610749] cAMP dissociates PKA, promoting GLI processing - Bos taurus [Pathway:R-BTA-5610785] GLI3 is processed to GLI3R by the proteasome - Bos taurus [BlackBoxEvent:R-BTA-5610752] GLI3R translocates to the nucleus - Bos taurus [Pathway:R-BTA-5610780] Degradation of GLI1 by the proteasome - Bos taurus
inferredFrom	[Pathway:R-HSA-5610787] Hedgehog 'off' state - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Hedgehog 'off' state
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-5610787
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5358351] Signaling by Hedgehog
(hasEncapsulatedEvent)	[Pathway:R-BTA-8878166] Transcriptional regulation by RUNX2
(inferredTo)	[Pathway:R-HSA-5610787] Hedgehog 'off' state

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