Reactome | Expression of PTCH1 is repressed by GLI3R in the absence of Hh signaling

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Expression of PTCH1 is repressed by GLI3R in the absence of Hh signaling Show undefined attributes

authored	[InstanceEdit:5610800] Rothfels, Karen, 2014-07-22
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:261122] ciliary membrane
created	[InstanceEdit:5612511] Rothfels, Karen, 2014-07-23
dbId	5612510
displayName	Expression of PTCH1 is repressed by GLI3R in the absence of Hh signaling
edited	[InstanceEdit:5617330] Gillespie, Marc E, 2014-07-25
eventOf	[Pathway:R-HSA-5610787] Hedgehog 'off' state - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5612503] PTCH1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5612471] Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site [LiteratureReference:5612485] Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis [LiteratureReference:5612467] A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb [LiteratureReference:5612477] Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning [LiteratureReference:5612493] Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Expression of PTCH1 is repressed by GLI3R in the absence of Hh signaling
output	[EntityWithAccessionedSequence:R-HSA-5610415] PTCH1 [ciliary membrane]
precedingEvent	[Reaction:R-HSA-5612508] GLI3R binds the PTCH1 promoter - Homo sapiens
regulatedBy	[NegativeGeneExpressionRegulation:R-HSA-5612509] Negative gene expression regulation by 'PTCH1 gene:GLI3R [nucleoplasm]'
releaseDate	2014-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5617331] Liu, Yulu Cherry, 2014-08-01
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5612510
summation	[Summation:5612500] Expression of the PTCH1 gene is repressed in the absence of ...

Referrals

(hasEvent)

[Pathway:R-HSA-5610787] Hedgehog 'off' state

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