Reactome | KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules

Schema > Reaction > Entries

KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules Show undefined attributes

authored	[InstanceEdit:5422974] Rothfels, Karen, 2014-05-07
category	binding
compartment	[Compartment:5263228] ciliary tip
created	[InstanceEdit:5610734] Rothfels, Karen, 2014-07-22
dbId	5610733
displayName	KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules
edited	[InstanceEdit:5617330] Gillespie, Marc E, 2014-07-25
eventOf	[Pathway:R-HSA-5610787] Hedgehog 'off' state - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5610395] KIF7 [ciliary tip] [Polymer:R-HSA-5610520] microtubule [axonemal microtubule]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5609857] The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment [LiteratureReference:5609686] A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes [LiteratureReference:5609768] Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components [LiteratureReference:5609737] Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function [LiteratureReference:5609854] The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling [LiteratureReference:5609775] Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation [LiteratureReference:5610134] Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling [LiteratureReference:5609787] Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling [LiteratureReference:5609864] The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development [LiteratureReference:5617323] Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules
orthologousEvent	[Reaction:R-DDI-5610733] KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules - Dictyostelium discoideum [Reaction:R-SSC-5610733] KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules - Sus scrofa [Reaction:R-CFA-5610733] KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules - Canis familiaris [Reaction:R-RNO-5610733] KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules - Rattus norvegicus [Reaction:R-MMU-5610733] KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules - Mus musculus
output	[Complex:R-HSA-5610559] KIF7:microtubule [ciliary tip]
releaseDate	2014-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5617331] Liu, Yulu Cherry, 2014-08-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5610733
summation	[Summation:5610678] KIF7, the human ortholog of Drosophila COS2, is a kinesin-4 ...

Referrals

(hasEvent)

[Pathway:R-HSA-5610787] Hedgehog 'off' state