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Degradation of GLI1 by the proteasome
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authored
[InstanceEdit:5422974] Rothfels, Karen, 2014-05-07
created
[InstanceEdit:5610781] Rothfels, Karen, 2014-07-22
dbId
5610780
displayName
Degradation of GLI1 by the proteasome
edited
[InstanceEdit:5617330] Gillespie, Marc E, 2014-07-25
eventOf
[Pathway:R-HSA-5610787] Hedgehog 'off' state - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-5610741] PKA phosphorylates GLI1 - Homo sapiens
[Reaction:R-HSA-5610742] SCF(beta-TrCP) ubiquitinates p-GLI1 - Homo sapiens
[BlackBoxEvent:R-HSA-5610758] GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP - Homo sapiens
[Reaction:R-HSA-5610735] NUMB binds ITCH - Homo sapiens
[Reaction:R-HSA-5610737] NUMB:ITCH bind and ubiquitnate GLI1 - Homo sapiens
[BlackBoxEvent:R-HSA-5610760] GLI1 is degraded by the proteasome after ubiquitination by ITCH - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5609839] Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3
[LiteratureReference:5609748] Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
[LiteratureReference:5609783] Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
[LiteratureReference:5609688] A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome
[LiteratureReference:5609692] A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome
modified
[InstanceEdit:10655440] Wright, Adam, 2024-03-08
name
Degradation of GLI1 by the proteasome
orthologousEvent
[Pathway:R-DME-5610780] Degradation of GLI1 by the proteasome - Drosophila melanogaster
[Pathway:R-GGA-5610780] Degradation of GLI1 by the proteasome - Gallus gallus
[Pathway:R-XTR-5610780] Degradation of GLI1 by the proteasome - Xenopus tropicalis
[Pathway:R-DRE-5610780] Degradation of GLI1 by the proteasome - Danio rerio
[Pathway:R-SSC-5610780] Degradation of GLI1 by the proteasome - Sus scrofa
[Pathway:R-BTA-5610780] Degradation of GLI1 by the proteasome - Bos taurus
[Pathway:R-CFA-5610780] Degradation of GLI1 by the proteasome - Canis familiaris
[Pathway:R-RNO-5610780] Degradation of GLI1 by the proteasome - Rattus norvegicus
[Pathway:R-MMU-5610780] Degradation of GLI1 by the proteasome - Mus musculus
releaseDate
2014-09-30
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5617331] Liu, Yulu Cherry, 2014-08-01
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5610780
summation
[Summation:5610658] GLI1 is the most divergent of the 3 mammalian GLI transcript...
Referrals
(hasEvent)
[Pathway:R-HSA-5610787] Hedgehog 'off' state
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