Reactome | Degradation of GLI1 by the proteasome

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Degradation of GLI1 by the proteasome Show undefined attributes

authored	[InstanceEdit:5422974] Rothfels, Karen, 2014-05-07
created	[InstanceEdit:5610781] Rothfels, Karen, 2014-07-22
dbId	5610780
displayName	Degradation of GLI1 by the proteasome
edited	[InstanceEdit:5617330] Gillespie, Marc E, 2014-07-25
eventOf	[Pathway:R-HSA-5610787] Hedgehog 'off' state - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5610741] PKA phosphorylates GLI1 - Homo sapiens [Reaction:R-HSA-5610742] SCF(beta-TrCP) ubiquitinates p-GLI1 - Homo sapiens [BlackBoxEvent:R-HSA-5610758] GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP - Homo sapiens [Reaction:R-HSA-5610735] NUMB binds ITCH - Homo sapiens [Reaction:R-HSA-5610737] NUMB:ITCH bind and ubiquitnate GLI1 - Homo sapiens [BlackBoxEvent:R-HSA-5610760] GLI1 is degraded by the proteasome after ubiquitination by ITCH - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5609839] Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3 [LiteratureReference:5609748] Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway [LiteratureReference:5609783] Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation [LiteratureReference:5609688] A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome [LiteratureReference:5609692] A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome
maxDepth	2
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Degradation of GLI1 by the proteasome
orthologousEvent	[Pathway:R-DME-5610780] Degradation of GLI1 by the proteasome - Drosophila melanogaster [Pathway:R-GGA-5610780] Degradation of GLI1 by the proteasome - Gallus gallus [Pathway:R-XTR-5610780] Degradation of GLI1 by the proteasome - Xenopus tropicalis [Pathway:R-DRE-5610780] Degradation of GLI1 by the proteasome - Danio rerio [Pathway:R-SSC-5610780] Degradation of GLI1 by the proteasome - Sus scrofa [Pathway:R-BTA-5610780] Degradation of GLI1 by the proteasome - Bos taurus [Pathway:R-CFA-5610780] Degradation of GLI1 by the proteasome - Canis familiaris [Pathway:R-RNO-5610780] Degradation of GLI1 by the proteasome - Rattus norvegicus [Pathway:R-MMU-5610780] Degradation of GLI1 by the proteasome - Mus musculus
releaseDate	2014-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5617331] Liu, Yulu Cherry, 2014-08-01
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5610780
summation	[Summation:5610658] GLI1 is the most divergent of the 3 mammalian GLI transcript...

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[Pathway:R-HSA-5610787] Hedgehog 'off' state

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