Reactome | Degradation of GLI2 by the proteasome

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Degradation of GLI2 by the proteasome Show undefined attributes

authored	[InstanceEdit:5422974] Rothfels, Karen, 2014-05-07
created	[InstanceEdit:5610782] Rothfels, Karen, 2014-07-22
dbId	5610783
displayName	Degradation of GLI2 by the proteasome
edited	[InstanceEdit:5617330] Gillespie, Marc E, 2014-07-25
eventOf	[Pathway:R-HSA-5610787] Hedgehog 'off' state - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5610717] PKA phosphorylates GLI2 - Homo sapiens [Reaction:R-HSA-5610718] CK1 phosphorylates p-GLI2 - Homo sapiens [Reaction:R-HSA-5610730] GSK3 phosphorylates p-GLI2 - Homo sapiens [Reaction:R-HSA-5610745] SCF(beta-TrCP) ubiquitinates p-GLI2 - Homo sapiens [BlackBoxEvent:R-HSA-5610757] GLI2 is degraded by the proteasome - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5358245] The mechanisms of Hedgehog signalling and its roles in development and disease [LiteratureReference:5609832] Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development [LiteratureReference:5609843] Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation [LiteratureReference:5609688] A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome
maxDepth	2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Degradation of GLI2 by the proteasome
releaseDate	2014-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5617331] Liu, Yulu Cherry, 2014-08-01
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5610783
summation	[Summation:5610696] The primary role of the GLI2 protein is as an activator of H...

Referrals

(hasEvent)

[Pathway:R-HSA-5610787] Hedgehog 'off' state