Reactome | GLI3R binds the GLI1 promoter

Schema > Reaction > Entries

GLI3R binds the GLI1 promoter Show undefined attributes

authored	[InstanceEdit:5610800] Rothfels, Karen, 2014-07-22
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5617407] Rothfels, Karen, 2014-08-06
dbId	5617408
displayName	GLI3R binds the GLI1 promoter
edited	[InstanceEdit:5617330] Gillespie, Marc E, 2014-07-25
eventOf	[Pathway:R-HSA-5610787] Hedgehog 'off' state - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5617412] Expression of GLI1 is repressed by GLI3R in the absence of Hh signaling - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5617393] GLI1 gene [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5610371] GLI3R [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5612498] The GLI gene encodes a nuclear protein which binds specific sequences in the human genome [LiteratureReference:5358220] Gli proteins in development and disease [LiteratureReference:5617320] GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GLI3R binds the GLI1 promoter
output	[Complex:R-HSA-5617398] GLI1 gene:GLI3R [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-5610752] GLI3R translocates to the nucleus - Homo sapiens
releaseDate	2014-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5617331] Liu, Yulu Cherry, 2014-08-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5617408
summation	[Summation:5617402] GLI3R is a DNA-binding transcriptional repressor that recogn...

Referrals

(hasEvent)	[Pathway:R-HSA-5610787] Hedgehog 'off' state
(precedingEvent)	[BlackBoxEvent:R-HSA-5617412] Expression of GLI1 is repressed by GLI3R in the absence of Hh signaling

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