Reactome | The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base

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The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base Show undefined attributes

authored	[InstanceEdit:5609897] Rothfels, Karen, 2014-07-16
category	omitted
compartment	[Compartment:5263232] ciliary base
created	[InstanceEdit:5610765] Rothfels, Karen, 2014-07-22
dbId	5610766
displayName	The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base
edited	[InstanceEdit:5617330] Gillespie, Marc E, 2014-07-25
eventOf	[Pathway:R-HSA-5610787] Hedgehog 'off' state - Homo sapiens
followingEvent	[Reaction:R-HSA-5610717] PKA phosphorylates GLI2 - Homo sapiens [Reaction:R-HSA-5610720] PKA phosphorylates GLI3 - Homo sapiens [Reaction:R-HSA-5610741] PKA phosphorylates GLI1 - Homo sapiens
input	[Complex:R-HSA-5621783] GLI:SUFU [ciliary tip]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5609878] The primary cilium: a signalling centre during vertebrate development [LiteratureReference:5609775] Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation [LiteratureReference:5609686] A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes [LiteratureReference:5610185] Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus [LiteratureReference:5609737] Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function [LiteratureReference:5610192] Hedgehog signalling in the mouse requires intraflagellar transport proteins [LiteratureReference:5610299] THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia [LiteratureReference:5610217] Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors [LiteratureReference:5610201] Hippi is essential for node cilia assembly and Sonic hedgehog signaling [LiteratureReference:5609707] Cilia and Hedgehog responsiveness in the mouse [LiteratureReference:5610209] Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli [LiteratureReference:5610152] Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4 [LiteratureReference:5610159] Ftm is a novel basal body protein of cilia involved in Shh signalling [LiteratureReference:5610219] Oral-facial-digital type I protein is required for primary cilia formation and left-right axis specification [LiteratureReference:5610121] A mouse model for Meckel syndrome reveals Mks1 is required for ciliogenesis and Hedgehog signaling [LiteratureReference:5609857] The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment [LiteratureReference:5609787] Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling [LiteratureReference:5609768] Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components [LiteratureReference:5610246] PCP effector gene Inturned is an important regulator of cilia formation and embryonic development in mammals [LiteratureReference:5610264] Planar cell polarity effector gene Fuzzy regulates cilia formation and Hedgehog signal transduction in mouse [LiteratureReference:5610314] The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development [LiteratureReference:5610139] Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base
orthologousEvent	[BlackBoxEvent:R-DME-5610766] The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base - Drosophila melanogaster [BlackBoxEvent:R-GGA-5610766] The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base - Gallus gallus [BlackBoxEvent:R-XTR-5610766] The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base - Xenopus tropicalis [BlackBoxEvent:R-DRE-5610766] The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base - Danio rerio [BlackBoxEvent:R-SSC-5610766] The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base - Sus scrofa [BlackBoxEvent:R-BTA-5610766] The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base - Bos taurus [BlackBoxEvent:R-CFA-5610766] The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base - Canis familiaris [BlackBoxEvent:R-RNO-5610766] The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base - Rattus norvegicus [BlackBoxEvent:R-MMU-5610766] The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base - Mus musculus
output	[Complex:R-HSA-5621787] GLI:SUFU [ciliary base]
regulatedBy	[PositiveRegulation:R-HSA-5610771] Positive regulation by 'ciliary basal body regulators of Hh [cytosol]' [PositiveRegulation:R-HSA-5610776] Positive regulation by 'retrograde IFT regulators of Hh [cilium]' [PositiveRegulation:R-HSA-5610777] Positive regulation by 'PCP regulators of Hh [cytosol]'
releaseDate	2014-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5617331] Liu, Yulu Cherry, 2014-08-01
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5610766
summation	[Summation:5610700] Vertebrate hedgehog signaling depends on the passage and/or ...

Referrals

(hasEvent)	[Pathway:R-HSA-5610787] Hedgehog 'off' state
(precedingEvent)	[Reaction:R-HSA-5610717] PKA phosphorylates GLI2 [Reaction:R-HSA-5610741] PKA phosphorylates GLI1 [Reaction:R-HSA-5610720] PKA phosphorylates GLI3

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