Reactome | Formation of MSH2:MSH6 Complex

Schema > Reaction > Entries

Formation of MSH2:MSH6 Complex Show undefined attributes

authored	[InstanceEdit:5423600] Gillespie, Marc E, 2014-05-09
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5444519] Gillespie, Marc E, 2014-05-14
dbId	5444516
diseaseReaction	[FailedReaction:R-HSA-5632970] MSH6 variant:MSH2-defective DNA mismatch repair - Homo sapiens [FailedReaction:R-HSA-5577244] MSH2 variant:MSH6-defective DNA mismatch repair - Homo sapiens
displayName	Formation of MSH2:MSH6 Complex
edited	[InstanceEdit:8980657] Gillespie, Marc E, 2017-02-28
eventOf	[Pathway:R-HSA-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - Homo sapiens
followingEvent	[Reaction:R-HSA-5358525] MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5357525] MSH2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5357528] MSH6 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5444524] Mutation of a mutL homolog in hereditary colon cancer
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Formation of MSH2:MSH6 Complex
orthologousEvent	[Reaction:R-MMU-5444516] Formation of MSH2:MSH6 Complex - Mus musculus [Reaction:R-PFA-5444516] Formation of MSH2:MSH6 Complex - Plasmodium falciparum [Reaction:R-SCE-5444516] Formation of MSH2:MSH6 Complex - Saccharomyces cerevisiae [Reaction:R-SPO-5444516] Formation of MSH2:MSH6 Complex - Schizosaccharomyces pombe [Reaction:R-DDI-5444516] Formation of MSH2:MSH6 Complex - Dictyostelium discoideum [Reaction:R-DME-5444516] Formation of MSH2:MSH6 Complex - Drosophila melanogaster [Reaction:R-GGA-5444516] Formation of MSH2:MSH6 Complex - Gallus gallus [Reaction:R-XTR-5444516] Formation of MSH2:MSH6 Complex - Xenopus tropicalis [Reaction:R-DRE-5444516] Formation of MSH2:MSH6 Complex - Danio rerio [Reaction:R-SSC-5444516] Formation of MSH2:MSH6 Complex - Sus scrofa [Reaction:R-BTA-5444516] Formation of MSH2:MSH6 Complex - Bos taurus [Reaction:R-CFA-5444516] Formation of MSH2:MSH6 Complex - Canis familiaris [Reaction:R-RNO-5444516] Formation of MSH2:MSH6 Complex - Rattus norvegicus
output	[Complex:R-HSA-5357523] MSH2:MSH6:ADP [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-6806394] TP53 and AP-1 stimulate MSH2 expression - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5566522] Edelbrock, Michael A, 2014-05-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5444516
summation	[Summation:6790098] MSH2 and MSH6 are mismatch DNA repair genes that act togethe...

Referrals

(normalReaction)	[FailedReaction:R-HSA-5632970] MSH6 variant:MSH2-defective DNA mismatch repair [FailedReaction:R-HSA-5577244] MSH2 variant:MSH6-defective DNA mismatch repair
(hasEvent)	[Pathway:R-HSA-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
(precedingEvent)	[Reaction:R-HSA-5358525] MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop