Reactome | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)

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Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Show undefined attributes

authored	[InstanceEdit:5358529] May, B, 2014-03-28
created	[InstanceEdit:5358539] May, Bruce, 2014-03-30
dbId	5358565
displayName	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
edited	[InstanceEdit:5358529] May, B, 2014-03-28
eventOf	[Pathway:R-HSA-5358508] Mismatch Repair - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:17157] mismatch repair
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5444516] Formation of MSH2:MSH6 Complex - Homo sapiens [Reaction:R-HSA-5358525] MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop - Homo sapiens [Reaction:R-HSA-5358912] MSH2:MSH6 exchanges ADP for ATP - Homo sapiens [Reaction:R-HSA-5444523] Formation of MSH1:PMS2 Complex - Homo sapiens [Reaction:R-HSA-5358510] MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA - Homo sapiens [Reaction:R-HSA-5358518] MLH1:PMS2 makes single strand incision near 1-2 base mismatch - Homo sapiens [Reaction:R-HSA-5358597] EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) - Homo sapiens [BlackBoxEvent:R-HSA-5358599] EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch - Homo sapiens [Reaction:R-HSA-5358579] DNA polymerase delta polymerizes DNA across single stranded gap - Homo sapiens [Reaction:R-HSA-5358592] DNA ligase I ligates single stranded nick in double stranded DNA - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5358855] Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activities [LiteratureReference:5358608] DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair [LiteratureReference:5358962] Mismatch repair deficiency associated with overexpression of the MSH3 gene
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
orthologousEvent	[Pathway:R-PFA-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - Plasmodium falciparum [Pathway:R-SCE-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - Saccharomyces cerevisiae [Pathway:R-SPO-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - Schizosaccharomyces pombe [Pathway:R-DDI-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - Dictyostelium discoideum [Pathway:R-CEL-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - Caenorhabditis elegans [Pathway:R-DME-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - Drosophila melanogaster [Pathway:R-GGA-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - Gallus gallus [Pathway:R-DRE-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - Danio rerio [Pathway:R-SSC-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - Sus scrofa [Pathway:R-BTA-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - Bos taurus [Pathway:R-CFA-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - Canis familiaris [Pathway:R-RNO-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - Rattus norvegicus [Pathway:R-MMU-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - Mus musculus
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5566522] Edelbrock, Michael A, 2014-05-23
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5358565
summation	[Summation:5358955] MSH2:MSH6 (MutSalpha) binds single base mismatches and unpai...

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[Pathway:R-HSA-5358508] Mismatch Repair

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