Reactome | TP53 and AP-1 stimulate MSH2 expression

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TP53 and AP-1 stimulate MSH2 expression Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6806398] Orlic-Milacic, Marija, 2015-10-22
dbId	6806394
displayName	TP53 and AP-1 stimulate MSH2 expression
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6796648] TP53 Regulates Transcription of DNA Repair Genes - Homo sapiens
followingEvent	[Reaction:R-HSA-5444511] Formation of MSH2:MSH3 Complex - Homo sapiens [Reaction:R-HSA-5444516] Formation of MSH2:MSH6 Complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-6806564] MSH2 Gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6806409] p53 and c-Jun functionally synergize in the regulation of the DNA repair gene hMSH2 in response to UV [LiteratureReference:6806400] Identification of a p53 response element in the promoter region of the hMSH2 gene required for expression in A2780 ovarian cancer cells
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 and AP-1 stimulate MSH2 expression
output	[EntityWithAccessionedSequence:R-HSA-5357525] MSH2 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6806412] TP53 and AP-1 bind the MSH2 promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-6806569] Positive gene expression regulation by 'AP-1:p-S15,S20-TP53 Tetramer:MSH2 Gene [nucleoplasm]'
regulationReference	[RegulationReference:9642890] Positive gene expression regulation by 'AP-1:p-S15,S20-TP53 Tetramer:MSH2 Gene [nucleoplasm]' p53 and c-Jun functionally synergize in the regulation of the DNA repair gene hMSH2 in response to UV
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-6806394
summation	[Summation:6806567] TP53 and the AP-1 transcription factor complex cooperatively...

Referrals

(precedingEvent)	[Reaction:R-HSA-5444511] Formation of MSH2:MSH3 Complex [Reaction:R-HSA-5444516] Formation of MSH2:MSH6 Complex
(hasEvent)	[Pathway:R-HSA-6796648] TP53 Regulates Transcription of DNA Repair Genes