Reactome | Formation of MSH2:MSH6 Complex

Schema > Reaction > Entries

Formation of MSH2:MSH6 Complex Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10698105
displayName	Formation of MSH2:MSH6 Complex
eventOf	[Pathway:R-XTR-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-5358525] MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-5444516] Formation of MSH2:MSH6 Complex - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-XTR-5357525] msh2 [nucleoplasm] [EntityWithAccessionedSequence:R-XTR-5357528] msh6 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Formation of MSH2:MSH6 Complex
output	[Complex:R-XTR-5357523] MSH2:MSH6:ADP [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-5444516
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
(precedingEvent)	[Reaction:R-XTR-5358525] MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop
(inferredTo)	[Reaction:R-HSA-5444516] Formation of MSH2:MSH6 Complex