Reactome | MSH2 variant:MSH6-defective DNA mismatch repair

Schema > FailedReaction > Entries

authored	[InstanceEdit:5575595] Gillespie, Marc E, 2014-05-24
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5577242] Gillespie, Marc E, 2014-05-30
crossReference	[DatabaseIdentifier:12020752] Mondo:0005575
dbId	5577244
disease	[Disease:4791250] colorectal cancer
displayName	MSH2 variant:MSH6-defective DNA mismatch repair
edited	[InstanceEdit:8980657] Gillespie, Marc E, 2017-02-28
entityFunctionalStatus	[EntityFunctionalStatus:5577245] loss_of_function of MSH2 Variants [nucleoplasm]
eventOf	[Pathway:R-HSA-5632928] Defective Mismatch Repair Associated With MSH2 - Homo sapiens
input	[DefinedSet:R-HSA-5577247] MSH2 Variants [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5357528] MSH6 [nucleoplasm]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:3642241] Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer [LiteratureReference:5577250] Structure of the human MSH2 locus and analysis of two Muir-Torre kindreds for msh2 mutations
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MSH2 variant:MSH6-defective DNA mismatch repair
normalReaction	[Reaction:R-HSA-5444516] Formation of MSH2:MSH6 Complex
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8944056] Arora, Sanjeevani, 2016-11-01
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5577244
summation	[Summation:8979929] MSH2 is homologous to the E. coli MutS gene and is involved ...

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