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Schema
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Entries
MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop
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authored
[InstanceEdit:5358529] May, B, 2014-03-28
category
binding
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:5358520] May, Bruce, 2014-03-29
dbId
5358525
displayName
MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop
edited
[InstanceEdit:5358529] May, B, 2014-03-28
eventOf
[Pathway:R-HSA-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - Homo sapiens
followingEvent
[Reaction:R-HSA-5358912] MSH2:MSH6 exchanges ADP for ATP - Homo sapiens
input
[OtherEntity:R-ALL-5358514] DNA containing mismatch or 1-2 base IDL [nucleoplasm]
[Complex:R-HSA-5357523] MSH2:MSH6:ADP [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5358638] hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci
[LiteratureReference:5358608] DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair
[LiteratureReference:5358566] MutSbeta exceeds MutSalpha in dinucleotide loop repair
[LiteratureReference:5358607] Distinct nucleotide binding/hydrolysis properties and molar ratio of MutSalpha and MutSbeta determine their differential mismatch binding activities
[LiteratureReference:5357511] Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha
[LiteratureReference:5358580] Human mismatch repair: reconstitution of a nick-directed bidirectional reaction
[LiteratureReference:5358604] Reconstitution of 5'-directed human mismatch repair in a purified system
[LiteratureReference:5358898] Structure of the human MutSalpha DNA lesion recognition complex
[LiteratureReference:5358855] Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activities
[LiteratureReference:5358890] Mismatch recognition and DNA-dependent stimulation of the ATPase activity of hMutSalpha is abolished by a single mutation in the hMSH6 subunit
[LiteratureReference:5358868] The role of mismatched nucleotides in activating the hMSH2-hMSH6 molecular switch
[LiteratureReference:5364043] The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutS?
modified
[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name
MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop
MutSalpha binds mismatch or 1-2 base insertion/deletion loop
orthologousEvent
[Reaction:R-PFA-5358525] MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop - Plasmodium falciparum
[Reaction:R-SCE-5358525] MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop - Saccharomyces cerevisiae
[Reaction:R-SPO-5358525] MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop - Schizosaccharomyces pombe
[Reaction:R-DDI-5358525] MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop - Dictyostelium discoideum
[Reaction:R-CEL-5358525] MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop - Caenorhabditis elegans
[Reaction:R-DME-5358525] MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop - Drosophila melanogaster
[Reaction:R-GGA-5358525] MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop - Gallus gallus
[Reaction:R-DRE-5358525] MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop - Danio rerio
[Reaction:R-SSC-5358525] MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop - Sus scrofa
[Reaction:R-BTA-5358525] MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop - Bos taurus
[Reaction:R-CFA-5358525] MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop - Canis familiaris
[Reaction:R-RNO-5358525] MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop - Rattus norvegicus
[Reaction:R-MMU-5358525] MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop - Mus musculus
output
[Complex:R-HSA-5358524] MSH2:MSH6:ADP:DNA containing 1-2 base mismatch [nucleoplasm]
precedingEvent
[Reaction:R-HSA-5444516] Formation of MSH2:MSH6 Complex - Homo sapiens
releaseDate
2014-06-10
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5566522] Edelbrock, Michael A, 2014-05-23
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5358525
summation
[Summation:5358865] The MSH2:MSH6 (MutSalpha) heterodimer binds single base mism...
Referrals
(hasEvent)
[Pathway:R-HSA-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
(precedingEvent)
[Reaction:R-HSA-5358912] MSH2:MSH6 exchanges ADP for ATP
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