Reactome | BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL

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BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL Show undefined attributes

authored	[InstanceEdit:508160] Matthews, L, 2010-02-08
category	binding
compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:508156] Matthews, L, 2010-02-10
dbId	508162
deleted	[Deleted:508172] Deletion of instance: 114278 [Deleted:622299] Deletion of instance: 114276 [Deleted:508173] Deletion of instance: 140232 [Deleted:508170] Deletion of instance: 114365 [Deleted:508174] Deletion of instance: 114281
displayName	BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL
edited	[InstanceEdit:508160] Matthews, L, 2010-02-08
eventOf	[Pathway:R-HSA-111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - Homo sapiens
input	[DefinedSet:R-HSA-508161] Bcl-XL interacting BH3-only proteins [mitochondrial outer membrane] [EntityWithAccessionedSequence:R-HSA-114236] BCL2L1 [mitochondrial outer membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:114451] Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed [LiteratureReference:140464] The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex [LiteratureReference:140450] PUMA, a novel proapoptotic gene, is induced by p53 [LiteratureReference:114467] Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD [LiteratureReference:140387] Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL
orthologousEvent	[Reaction:R-GGA-508162] BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL - Gallus gallus [Reaction:R-XTR-508162] BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL - Xenopus tropicalis [Reaction:R-DRE-508162] BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL - Danio rerio [Reaction:R-SSC-508162] BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL - Sus scrofa [Reaction:R-BTA-508162] BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL - Bos taurus [Reaction:R-CFA-508162] BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL - Canis familiaris [Reaction:R-RNO-508162] BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL - Rattus norvegicus [Reaction:R-MMU-508162] BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL - Mus musculus
output	[Complex:R-HSA-508159] Bcl-XL:BH3-only protein complex [mitochondrial outer membrane]
precedingEvent	[Reaction:R-HSA-139920] Translocation of tBID to mitochondria - Homo sapiens [Reaction:R-HSA-139914] Translocation of BBC3 (PUMA) protein to mitochondria - Homo sapiens [Reaction:R-HSA-139905] Translocation of activated BAD protein to mitochondria - Homo sapiens [Reaction:R-HSA-140216] Translocation of PMAIP1 (NOXA) to mitochondria - Homo sapiens [Reaction:R-HSA-139919] Translocation of BIM to mitochondria - Homo sapiens
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-508162
summation	[Summation:508155] BH3-only proteins (tBid, BIM, PUMA, BAD, NOXA) associate wit...

Referrals

(replacementInstances)	[Deleted:508172] Deletion of instance: 114278 [Deleted:622299] Deletion of instance: 114276 [Deleted:508173] Deletion of instance: 140232 [Deleted:508170] Deletion of instance: 114365 [Deleted:508174] Deletion of instance: 114281
(hasEvent)	[Pathway:R-HSA-111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

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