Reactome | BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL

Schema > Reaction > Entries

BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL Show undefined attributes

category	binding
compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10482002
displayName	BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL
eventOf	[Pathway:R-SSC-111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-508162] BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL - Homo sapiens
input	[DefinedSet:R-SSC-508161] Bcl-XL interacting BH3-only proteins [mitochondrial outer membrane] [EntityWithAccessionedSequence:R-SSC-114236] BCL2L1 [mitochondrial outer membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL
output	[Complex:R-SSC-508159] Bcl-XL:BH3-only protein complex [mitochondrial outer membrane]
precedingEvent	[Reaction:R-SSC-139920] Translocation of tBID to mitochondria - Sus scrofa [Reaction:R-SSC-139905] Translocation of activated BAD protein to mitochondria - Sus scrofa [Reaction:R-SSC-140216] Translocation of PMAIP1 (NOXA) to mitochondria - Sus scrofa [Reaction:R-SSC-139919] Translocation of BIM to mitochondria - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-508162
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
(inferredTo)	[Reaction:R-HSA-508162] BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL

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