BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL

Stable Identifier
Reaction [binding]
Homo sapiens
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BH3-only proteins (tBid, BIM, PUMA, BAD, NOXA) associate with and inactivate anti-apoptotic protein Bcl-XL( Yi et al., 2003; Puthalakath et al., 1999; Nakano and Vousden, 2001; Wang et al., 1999; Oda et al., 2000). The interactions of NOXA with Bcl-XL are inferred from experiments performed in mice (Oda et al., 2000).
Literature References
PubMed ID Title Journal Year
10195903 Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

Shibasaki, F, Franke, TF, Wang, HG, Yamaguchi, Y, Krajewski, S, Pathan, N, McKeon, F, Reed, JC, Ethell, IM, Bobo, T

Science 1999
10198631 The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

O'Reilly, LA, Puthalakath, H, Strasser, A, King, SM, Huang, DC

Mol Cell 1999
12624108 Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed

Dong, Z, Yin, XM, Yi, X

J Biol Chem 2003
10807576 Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

Taniguchi, T, Tokino, T, Yamashita, T, Shibue, T, Ohki, R, Oda, E, Nemoto, J, Murasawa, H, Tanaka, N

Science 2000
11463392 PUMA, a novel proapoptotic gene, is induced by p53

Nakano, K, Vousden, KH

Mol Cell 2001
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