BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL

Stable Identifier
R-HSA-508162
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

BH3-only proteins (tBid, BIM, PUMA, BAD, NOXA) associate with and inactivate anti-apoptotic protein Bcl-XL( Yi et al., 2003; Puthalakath et al., 1999; Nakano and Vousden, 2001; Wang et al., 1999; Oda et al., 2000). The interactions of NOXA with Bcl-XL are inferred from experiments performed in mice (Oda et al., 2000).

Literature References
PubMed ID Title Journal Year
10195903 Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

Shibasaki, F, Franke, TF, Wang, HG, Yamaguchi, Y, Krajewski, S, Pathan, N, McKeon, F, Reed, JC, Ethell, IM, Bobo, T

Science 1999
10198631 The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

O'Reilly, LA, Puthalakath, H, Strasser, A, King, SM, Huang, DC

Mol Cell 1999
12624108 Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed

Dong, Z, Yin, XM, Yi, X

J Biol Chem 2003
10807576 Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

Taniguchi, T, Tokino, T, Yamashita, T, Shibue, T, Ohki, R, Oda, E, Nemoto, J, Murasawa, H, Tanaka, N

Science 2000
11463392 PUMA, a novel proapoptotic gene, is induced by p53

Nakano, K, Vousden, KH

Mol Cell 2001
Participants
Participates
Orthologous Events
Authored
Created
Cite Us!