Reactome | BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL

BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL

Stable Identifier

R-HSA-508162

Type

Reaction [binding]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

ReviewStatus

5/5

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BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL

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BH3-only proteins (tBid, BIM, PUMA, BAD, NOXA) associate with and inactivate anti-apoptotic protein Bcl-XL( Yi et al., 2003; Puthalakath et al., 1999; Nakano and Vousden, 2001; Wang et al., 1999; Oda et al., 2000). The interactions of NOXA with Bcl-XL are inferred from experiments performed in mice (Oda et al., 2000).

Literature References

PubMed ID	Title	Journal	Year
10195903	Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD Shibasaki, F, Franke, TF, Wang, HG, Yamaguchi, Y, Krajewski, S, Pathan, N, McKeon, F, Reed, JC, Ethell, IM, Bobo, T	Science	1999
10198631	The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex O'Reilly, LA, Puthalakath, H, Strasser, A, King, SM, Huang, DC	Mol Cell	1999
12624108	Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed Dong, Z, Yin, XM, Yi, X	J Biol Chem	2003
10807576	Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis Taniguchi, T, Tokino, T, Yamashita, T, Shibue, T, Ohki, R, Oda, E, Nemoto, J, Murasawa, H, Tanaka, N	Science	2000
11463392	PUMA, a novel proapoptotic gene, is induced by p53 Nakano, K, Vousden, KH	Mol Cell	2001