Reactome | BH3-only proteins (tBid, BIM, PUMA, BAD, NOXA) associate wit...

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created	[InstanceEdit:508156] Matthews, L, 2010-02-10
dbId	508155
displayName	BH3-only proteins (tBid, BIM, PUMA, BAD, NOXA) associate wit...
literatureReference	[LiteratureReference:114451] Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed [LiteratureReference:140464] The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex [LiteratureReference:140450] PUMA, a novel proapoptotic gene, is induced by p53 [LiteratureReference:114467] Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD [LiteratureReference:140387] Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
modified	[InstanceEdit:508168] Matthews, L, 2010-02-10
schemaClass	Summation
text	BH3-only proteins (tBid, BIM, PUMA, BAD, NOXA) associate with and inactivate anti-apoptotic protein Bcl-XL( Yi et al., 2003; Puthalakath et al., 1999; Nakano and Vousden, 2001; Wang et al., 1999; Oda et al., 2000). The interactions of NOXA with Bcl-XL are inferred from experiments performed in mice (Oda et al., 2000).

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