Reactome | SOX2 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

SOX2 [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-9833048] SOX2:ZEB2 gene [nucleoplasm] - Homo sapiens [Complex:R-HSA-9732119] SOX2:MITF gene [nucleoplasm] - Homo sapiens [Complex:R-HSA-2889030] POU5F1:SOX2:NANOG:ZIC3 gene [nucleoplasm] - Homo sapiens [Complex:R-HSA-6800114] POU5F1:SOX2:NANOG:DPPA4 gene [nucleoplasm] - Homo sapiens [Complex:R-HSA-9756939] FOXH1:SMAD3:POU5F1:NANOG:SOX2:EOMES gene [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9732125] SOX2 binds the MITF promoter - Homo sapiens [Reaction:R-HSA-9833066] SOX2 binds the ZEB2 gene - Homo sapiens [Reaction:R-HSA-9615536] MECP2 and SOX2 bind MIR137 gene - Homo sapiens [Reaction:R-HSA-9835623] POU5F1 and SOX2 bind the ZIC1 gene - Homo sapiens [Reaction:R-HSA-2972978] POU5F1 (OCT4), SOX2, NANOG bind the ZIC3 promoter - Homo sapiens [Reaction:R-HSA-2972977] POU5F1 (OCT4), SOX2, NANOG bind the DKK1 promoter - Homo sapiens [Reaction:R-HSA-2972965] POU5F1 (OCT4), SOX2, NANOG bind the TSC22D1 promoter - Homo sapiens [Reaction:R-HSA-1112609] POU5F1 (OCT4), SOX2, NANOG, ZSCAN10, PRDM14, SMAD2, FOXP1-ES bind the POU5F1 (OCT4) promoter - Homo sapiens [Reaction:R-HSA-480685] POU5F1 (OCT4), SOX2, NANOG bind the SOX2 promoter - Homo sapiens [Reaction:R-HSA-2972962] POU5F1 (OCT4), SOX2, NANOG bind the TDGF1 promoter - Homo sapiens [Reaction:R-HSA-2972956] POU5F1 (OCT4), SOX2, NANOG bind the STAT3 promoter - Homo sapiens [Reaction:R-HSA-6800120] POU5F1 (OCT4), SOX2, NANOG bind DPPA4 gene - Homo sapiens [Reaction:R-HSA-2972967] POU5F1 (OCT4), SOX2, NANOG bind the EPHA1 promoter - Homo sapiens [Reaction:R-HSA-2972964] POU5F1 (OCT4), SOX2, NANOG bind the FOXD3 promoter - Homo sapiens [Reaction:R-HSA-2972975] POU5F1 (OCT4), SOX2, NANOG Bind the SALL1 Promoter - Homo sapiens [Reaction:R-HSA-2972979] POU5F1 (OCT4), NANOG bind the CDX2 promoter - Homo sapiens [Reaction:R-HSA-2972966] POU5F1 (OCT4), SOX2, NANOG bind the HHEX promoter - Homo sapiens [Reaction:R-HSA-2972948] POU5F1 (OCT4), SOX2, NANOG bind the GSC promoter - Homo sapiens [Reaction:R-HSA-2972949] POU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter - Homo sapiens [Reaction:R-HSA-2972960] POU5F1 (OCT4), SOX2, NANOG bind the FGF2 promoter - Homo sapiens [Reaction:R-HSA-9835484] TFAP2A:TFAP2C, POU5F1, SOX2 and MYB bind the PAX7 gene - Homo sapiens [Reaction:R-HSA-480204] POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter - Homo sapiens
created	[InstanceEdit:452990] May, B, 2010-01-15
dbId	452271
displayName	SOX2 [nucleoplasm]
endCoordinate	317
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-452271] Sox2 [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-RNO-452271] SOX2 [nucleoplasm] - Rattus norvegicus [EntityWithAccessionedSequence:R-SSC-452271] Sox2 [nucleoplasm] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-452271] sox2 [nucleoplasm] - Danio rerio [EntityWithAccessionedSequence:R-XTR-452271] sox2 [nucleoplasm] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-452271] SOX2 [nucleoplasm] - Gallus gallus [EntityWithAccessionedSequence:R-DME-452271] Sox21a [nucleoplasm] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-452271] sox-2 [nucleoplasm] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-SPO-452271] mat1-Mc [nucleoplasm] - Schizosaccharomyces pombe [EntityWithAccessionedSequence:R-SCE-452271] ROX1 [nucleoplasm] - Saccharomyces cerevisiae
maxDepth	1
memberOf	[DefinedSet:R-HSA-5626912] SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] - Homo sapiens [DefinedSet:R-HSA-6790042] STAT3-upregulated nuclear proteins [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:3448660] Wu, G, 2013-05-16
name	SOX2 Transcription factor SOX-2 SOX2_HUMAN
positivelyRegulates	[PositiveGeneExpressionRegulation:480928] Positive gene expression regulation by 'SOX2 [nucleoplasm]'
producedByEvent	[BlackBoxEvent:R-HSA-9926523] MITF-M-dependent SOX2 gene expression - Homo sapiens [BlackBoxEvent:R-HSA-9832841] Expression of SOX2 in anterior neural plate - Homo sapiens [BlackBoxEvent:R-HSA-9832988] Expression of SOX2 in posterior neural plate - Homo sapiens [BlackBoxEvent:R-HSA-452894] Expression of SOX2 - Homo sapiens [Reaction:R-HSA-9754480] p-2S-SMAD2,3:SMAD4, CTNNB1, and TBPL2 bind FOXH1:SMAD3:EOMES gene - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:P48431] UniProt:P48431 SOX2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-452271
startCoordinate	1

Referrals

(hasComponent)	[Complex:R-HSA-9732119] SOX2:MITF gene [nucleoplasm] [Complex:R-HSA-6800114] POU5F1:SOX2:NANOG:DPPA4 gene [nucleoplasm] [Complex:R-HSA-2889030] POU5F1:SOX2:NANOG:ZIC3 gene [nucleoplasm] [Complex:R-HSA-2889014] POU5F1:SOX2:NANOG:EPHA1 gene [nucleoplasm] [Complex:R-HSA-2889032] POU5F1:SOX2:NANOG:FOXD3 gene [nucleoplasm] [Complex:R-HSA-2889029] POU5F1:SOX2:NANOG:SALL1 gene [nucleoplasm] [Complex:R-HSA-2889022] POU5F1:SOX2:NANOG:CDX2 gene [nucleoplasm] [Complex:R-HSA-2888998] POU5F1:SOX2:NANOG:DKK1 gene [nucleoplasm] [Complex:R-HSA-2889020] POU5F1:SOX2:NANOG:HHEX gene [nucleoplasm] [Complex:R-HSA-2889006] POU5F1:SOX2:NANOG:TSC22D1 gene [nucleoplasm] [Complex:R-HSA-2889015] POU5F1:SOX2:NANOG:FGF2 gene [nucleoplasm] [Complex:R-HSA-480463] POU5F1:SOX2:NANOG:KLF4:PBX1:SMAD2:FOXP1-ES:NANOG gene [nucleoplasm] [Complex:R-HSA-1112611] POU5F1:SOX2:NANOG:ZSCAN10:PRDM14:SMAD2:SALL4:FOXP1-ES:POU5F1 gene [nucleoplasm] [Complex:R-HSA-480572] POU5F1:SOX2:NANOG:SOX2 gene [nucleoplasm] [Complex:R-HSA-2889018] POU5F1:SOX2:NANOG:TDGF1 gene [nucleoplasm] [Complex:R-HSA-2889000] POU5F1:SOX2:NANOG:EOMES gene [nucleoplasm] [Complex:R-HSA-9756939] FOXH1:SMAD3:POU5F1:NANOG:SOX2:EOMES gene [nucleoplasm] [Complex:R-HSA-2889003] POU5F1:SOX2:NANOG:STAT3 gene [nucleoplasm] [Complex:R-HSA-9615538] MECP2:SOX2:MIR137 gene [nucleoplasm] [Complex:R-HSA-9835492] TFAP2A:TFAP2C:POU5F1:SOX2:MYB:PAX7 gene [nucleoplasm] [Complex:R-HSA-9835606] POU5F1:SOX2:ZIC1 gene [nucleoplasm] [Complex:R-HSA-2889033] POU5F1:SOX2:NANOG:GSC gene [nucleoplasm] [Complex:R-HSA-9833048] SOX2:ZEB2 gene [nucleoplasm]
(input)	[Reaction:R-HSA-9732125] SOX2 binds the MITF promoter [Reaction:R-HSA-6800120] POU5F1 (OCT4), SOX2, NANOG bind DPPA4 gene [Reaction:R-HSA-2972978] POU5F1 (OCT4), SOX2, NANOG bind the ZIC3 promoter [Reaction:R-HSA-2972967] POU5F1 (OCT4), SOX2, NANOG bind the EPHA1 promoter [Reaction:R-HSA-2972964] POU5F1 (OCT4), SOX2, NANOG bind the FOXD3 promoter [Reaction:R-HSA-2972975] POU5F1 (OCT4), SOX2, NANOG Bind the SALL1 Promoter [Reaction:R-HSA-2972979] POU5F1 (OCT4), NANOG bind the CDX2 promoter [Reaction:R-HSA-2972977] POU5F1 (OCT4), SOX2, NANOG bind the DKK1 promoter [Reaction:R-HSA-2972966] POU5F1 (OCT4), SOX2, NANOG bind the HHEX promoter [Reaction:R-HSA-2972948] POU5F1 (OCT4), SOX2, NANOG bind the GSC promoter [Reaction:R-HSA-2972965] POU5F1 (OCT4), SOX2, NANOG bind the TSC22D1 promoter [Reaction:R-HSA-2972949] POU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter [Reaction:R-HSA-9833066] SOX2 binds the ZEB2 gene [Reaction:R-HSA-2972960] POU5F1 (OCT4), SOX2, NANOG bind the FGF2 promoter [Reaction:R-HSA-480204] POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter [Reaction:R-HSA-1112609] POU5F1 (OCT4), SOX2, NANOG, ZSCAN10, PRDM14, SMAD2, FOXP1-ES bind the POU5F1 (OCT4) promoter [Reaction:R-HSA-480685] POU5F1 (OCT4), SOX2, NANOG bind the SOX2 promoter [Reaction:R-HSA-2972962] POU5F1 (OCT4), SOX2, NANOG bind the TDGF1 promoter [Reaction:R-HSA-2972956] POU5F1 (OCT4), SOX2, NANOG bind the STAT3 promoter [Reaction:R-HSA-9615536] MECP2 and SOX2 bind MIR137 gene [Reaction:R-HSA-9835484] TFAP2A:TFAP2C, POU5F1, SOX2 and MYB bind the PAX7 gene [Reaction:R-HSA-9835623] POU5F1 and SOX2 bind the ZIC1 gene
(output)	[BlackBoxEvent:R-HSA-9926523] MITF-M-dependent SOX2 gene expression [BlackBoxEvent:R-HSA-9832841] Expression of SOX2 in anterior neural plate [BlackBoxEvent:R-HSA-9832988] Expression of SOX2 in posterior neural plate [BlackBoxEvent:R-HSA-452894] Expression of SOX2 [Reaction:R-HSA-9754480] p-2S-SMAD2,3:SMAD4, CTNNB1, and TBPL2 bind FOXH1:SMAD3:EOMES gene
(hasMember)	[DefinedSet:R-HSA-6790042] STAT3-upregulated nuclear proteins [nucleoplasm] [DefinedSet:R-HSA-5626912] SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm]
(activeUnit)	[NegativeRegulation:9732120] Negative regulation by 'SOX2:MITF gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-452214] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:DPPA4 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-5638455] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:EPHA1 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-6800076] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:SALL1 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-5638453] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:ZIC3 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-5638447] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:FOXD3 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-5638457] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:FGF2 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-5638456] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:KLF4:PBX1:SMAD2:FOXP1-ES:NANOG gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-5638452] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:ZSCAN10:PRDM14:SMAD2:SALL4:FOXP1-ES:POU5F1 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-5638454] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:SOX2 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-5638449] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:TDGF1 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-5638448] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:STAT3 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:9615659] Negative gene expression regulation by 'MECP2:SOX2:MIR137 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9835626] Positive gene expression regulation by 'POU5F1:SOX2:ZIC1 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9833076] Positive gene expression regulation by 'SOX2:ZEB2 gene [nucleoplasm]'
(regulator)	[PositiveGeneExpressionRegulation:480928] Positive gene expression regulation by 'SOX2 [nucleoplasm]'

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