Reactome | POU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter

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POU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter Show undefined attributes

authored	[InstanceEdit:2901807] May, B, 2013-01-03
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2972945] D'Eustachio, P, 2013-01-06
dbId	2972949
displayName	POU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter
edited	[InstanceEdit:2901807] May, B, 2013-01-03
eventOf	[Pathway:R-HSA-2892245] POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2888969] EOMES gene [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-452586] NANOG [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-452472] POU5F1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-452271] SOX2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:452538] Core transcriptional regulatory circuitry in human embryonic stem cells [LiteratureReference:452628] Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells [LiteratureReference:1112612] A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells [LiteratureReference:2975839] Pluripotency factors regulate definitive endoderm specification through eomesodermin [LiteratureReference:5246719] Human DNA methylomes at base resolution show widespread epigenomic differences [LiteratureReference:5250252] Transposable elements have rewired the core regulatory network of human embryonic stem cells [LiteratureReference:5251124] Eomesodermin is required for mouse trophoblast development and mesoderm formation [LiteratureReference:5251136] Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	POU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter
output	[Complex:R-HSA-2889000] POU5F1:SOX2:NANOG:EOMES gene [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-452838] Expression of NANOG - Homo sapiens [BlackBoxEvent:R-HSA-452894] Expression of SOX2 - Homo sapiens [BlackBoxEvent:R-HSA-2889036] Translation of OCT4 mRNA - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5246708] Wang, Jianlong, 2014-01-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2972949
summation	[Summation:2972903] The EOMES gene is bound by POU5F1 (OCT4) (Boyer et al. 2005,...

Referrals

(hasEvent)

[Pathway:R-HSA-2892245] POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation