Reactome | POU5F1 (OCT4), SOX2, NANOG bind the FGF2 promoter

Schema > Reaction > Entries

POU5F1 (OCT4), SOX2, NANOG bind the FGF2 promoter Show undefined attributes

authored	[InstanceEdit:2901807] May, B, 2013-01-03
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2972945] D'Eustachio, P, 2013-01-06
dbId	2972960
displayName	POU5F1 (OCT4), SOX2, NANOG bind the FGF2 promoter
edited	[InstanceEdit:2901807] May, B, 2013-01-03
eventOf	[Pathway:R-HSA-2892247] POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-480515] Expression of FGF2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2888971] FGF2 gene [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-452586] NANOG [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-452472] POU5F1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-452271] SOX2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:452538] Core transcriptional regulatory circuitry in human embryonic stem cells [LiteratureReference:452628] Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells [LiteratureReference:5246719] Human DNA methylomes at base resolution show widespread epigenomic differences [LiteratureReference:2972933] Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	POU5F1 (OCT4), SOX2, NANOG bind the FGF2 promoter
output	[Complex:R-HSA-2889015] POU5F1:SOX2:NANOG:FGF2 gene [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-452838] Expression of NANOG - Homo sapiens [BlackBoxEvent:R-HSA-452894] Expression of SOX2 - Homo sapiens [BlackBoxEvent:R-HSA-2889036] Translation of OCT4 mRNA - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5246708] Wang, Jianlong, 2014-01-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2972960
summation	[Summation:2972911] The FGF2 gene is bound by POU5F1 (OCT4) (Boyer et al. 2005),...

Referrals

(hasEvent)	[Pathway:R-HSA-2892247] POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
(precedingEvent)	[BlackBoxEvent:R-HSA-480515] Expression of FGF2

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