Reactome | POU5F1:SOX2:NANOG:ZIC3 gene [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2888999] May, B, 2012-12-31
dbId	2889030
displayName	POU5F1:SOX2:NANOG:ZIC3 gene [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-HSA-452586] NANOG [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-452472] POU5F1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-452271] SOX2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-2888979] ZIC3 gene [nucleoplasm]
inDisease	false
isChimeric	false
literatureReference	[LiteratureReference:452538] Core transcriptional regulatory circuitry in human embryonic stem cells [LiteratureReference:2972938] Combinatorial binding in human and mouse embryonic stem cells identifies conserved enhancers active in early embryonic development [LiteratureReference:5246719] Human DNA methylomes at base resolution show widespread epigenomic differences
maxDepth	2
modified	[InstanceEdit:5250254] May, B, 2014-01-24
name	POU5F1:SOX2:NANOG:ZIC3 gene OCT4:SOX2:NANOG:ZIC3 gene
positivelyRegulates	[PositiveGeneExpressionRegulation:R-HSA-5638453] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:ZIC3 gene [nucleoplasm]'
producedByEvent	[Reaction:R-HSA-2972978] POU5F1 (OCT4), SOX2, NANOG bind the ZIC3 promoter - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-2889030

(output)	[Reaction:R-HSA-2972978] POU5F1 (OCT4), SOX2, NANOG bind the ZIC3 promoter
(regulator)	[PositiveGeneExpressionRegulation:R-HSA-5638453] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:ZIC3 gene [nucleoplasm]'

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