Reactome | POU5F1:SOX2:NANOG:EOMES gene [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2888999] May, B, 2012-12-31
dbId	2889000
displayName	POU5F1:SOX2:NANOG:EOMES gene [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-HSA-2888969] EOMES gene [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-452586] NANOG [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-452472] POU5F1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-452271] SOX2 [nucleoplasm]
inDisease	false
isChimeric	false
literatureReference	[LiteratureReference:452538] Core transcriptional regulatory circuitry in human embryonic stem cells [LiteratureReference:5246719] Human DNA methylomes at base resolution show widespread epigenomic differences [LiteratureReference:5246714] Identification of an OCT4 and SRY regulatory module using integrated computational and experimental genomics approaches [LiteratureReference:1112612] A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells
maxDepth	2
modified	[InstanceEdit:5250254] May, B, 2014-01-24
name	POU5F1:SOX2:NANOG:EOMES gene OCT4:SOX2:NANOG:EOMES gene
negativelyRegulates	[NegativeGeneExpressionRegulation:5163260] Negative gene expression regulation by 'POU5F1:SOX2:NANOG:EOMES gene [nucleoplasm]'
producedByEvent	[Reaction:R-HSA-2972949] POU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-2889000

(output)	[Reaction:R-HSA-2972949] POU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter
(regulator)	[NegativeGeneExpressionRegulation:5163260] Negative gene expression regulation by 'POU5F1:SOX2:NANOG:EOMES gene [nucleoplasm]'