Reactome | Phosphorylated MKK3/MKK6 migrates to nucleus

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Phosphorylated MKK3/MKK6 migrates to nucleus Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10760815
displayName	Phosphorylated MKK3/MKK6 migrates to nucleus
eventOf	[Pathway:R-GGA-450302] activated TAK1 mediates p38 MAPK activation - Gallus gallus [Pathway:R-GGA-2559580] Oxidative Stress Induced Senescence - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-8877691] MAP2K6 phosphorylates PIP4K2B - Gallus gallus [Reaction:R-GGA-3238999] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 - Gallus gallus [Reaction:R-GGA-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Gallus gallus
inferredFrom	[Reaction:R-HSA-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Homo sapiens
input	[DefinedSet:R-GGA-167984] p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylated MKK3/MKK6 migrates to nucleus
output	[DefinedSet:R-GGA-450343] p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm]
precedingEvent	[Reaction:R-GGA-450346] activated human TAK1 phosphorylates MKK3/MKK6 - Gallus gallus [Reaction:R-GGA-3228469] MAP3K5 phosphorylates MKK3 and MKK6 - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-450296
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-2559580] Oxidative Stress Induced Senescence [Pathway:R-GGA-450302] activated TAK1 mediates p38 MAPK activation
(precedingEvent)	[Reaction:R-GGA-8877691] MAP2K6 phosphorylates PIP4K2B [Reaction:R-GGA-3238999] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 [Reaction:R-GGA-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
(inferredTo)	[Reaction:R-HSA-450296] Phosphorylated MKK3/MKK6 migrates to nucleus