Reactome | activated MAPK3/MAPK6 migrates to nucleus

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activated MAPK3/MAPK6 migrates to nucleus Show undefined attributes

authored	[InstanceEdit:438031] Shamovsky, V, 2009-09-22
category	transition
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm [Compartment:13231] nuclear envelope
created	[InstanceEdit:442879] Shamovsky, V, 2009-09-29
dbId	442938
displayName	activated MAPK3/MAPK6 migrates to nucleus
edited	[InstanceEdit:668815] Shamovsky, V, 2010-05-04
eventOf	[Pathway:R-GGA-437980] Activated TAK1 mediates p38 MAP kinase phosphorylation - Gallus gallus
followingEvent	[Reaction:R-GGA-438019] activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Gallus gallus
inferredFrom	[Reaction:R-HSA-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Homo sapiens
input	[CandidateSet:R-GGA-437977] phospho MKK3/ phospho MKK6 [cytosol]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:442901] Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine [LiteratureReference:442922] Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	activated MAPK3/MAPK6 migrates to nucleus
output	[CandidateSet:R-GGA-442940] phospho MKK3/ phospho MKK6 [nucleoplasm]
precedingEvent	[Reaction:R-GGA-437984] Phosphorylation of MKK3/MKK6 by activated TAK1 - Gallus gallus
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:789693] D'Eustachio, P, 2010-05-23
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-442938
summation	[Summation:444070] The p38 activators MKK3 (MAP2K3) and MKK6 (MAP2K6) were pres...
updateTrackers	[UpdateTracker:9779820] Update Tracker - [Reaction:442938] activated MAPK3/MAPK6 migrates to nucleus - v64:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9779820] Update Tracker - [Reaction:442938] activated MAPK3/MAPK6 migrates to nucleus - v64:[modifyText]
(hasEvent)	[Pathway:R-GGA-437980] Activated TAK1 mediates p38 MAP kinase phosphorylation
(precedingEvent)	[Reaction:R-GGA-438019] activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
(inferredTo)	[Reaction:R-HSA-450296] Phosphorylated MKK3/MKK6 migrates to nucleus

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