Phosphorylated MKK3/MKK6 migrates to nucleus

Stable Identifier
R-HSA-450296
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The p38 activators MKK3 (MAP2K3) and MKK6 (MAP2K6) were present in both the nucleus and the cytoplasm, consistent with a role in activating p38 in the nucleus.
Literature References
PubMed ID Title Journal Year
9768359 Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2

Marshall, CJ, Hooper, S, Paterson, HF, Ben-Levy, R, Wilson, R

Curr Biol 1998
7535770 Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

Gupta, S, Davis, RJ, Ulevitch, RJ, Han, J, Raingeaud, J, Dickens, M, Rogers, JS

J Biol Chem 1995
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!