Phosphorylated MKK3/MKK6 migrates to nucleus

Stable Identifier
R-HSA-450296
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The p38 activators MKK3 (MAP2K3) and MKK6 (MAP2K6) were present in both the nucleus and the cytoplasm, consistent with a role in activating p38 in the nucleus.

Literature References
PubMed ID Title Journal Year
7535770 Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

Raingeaud, J, Gupta, S, Rogers, JS, Dickens, M, Han, J, Ulevitch, RJ, Davis, RJ

J Biol Chem 1995
9768359 Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2

Ben-Levy, R, Hooper, S, Wilson, R, Paterson, HF, Marshall, CJ

Curr Biol 1998
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