Reactome | Phosphorylated MKK3/MKK6 migrates to nucleus

Phosphorylated MKK3/MKK6 migrates to nucleus

Stable Identifier

R-HSA-450296

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-17 signaling (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)

General

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Phosphorylated MKK3/MKK6 migrates to nucleus

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The p38 activators MKK3 (MAP2K3) and MKK6 (MAP2K6) were present in both the nucleus and the cytoplasm, consistent with a role in activating p38 in the nucleus.

Literature References

PubMed ID	Title	Journal	Year
9768359	Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2 Ben-Levy, R, Hooper, S, Wilson, R, Paterson, HF, Marshall, CJ	Curr Biol	1998
7535770	Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine Raingeaud, J, Gupta, S, Rogers, JS, Dickens, M, Han, J, Ulevitch, RJ, Davis, RJ	J Biol Chem	1995