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Schema
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Reaction
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Entries
MAP3K5 phosphorylates MKK3 and MKK6
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authored
[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
catalystActivity
[CatalystActivity:3228467] protein serine/threonine kinase activity of MAP3K5 [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:3228463] Orlic-Milacic, M, 2013-03-25
dbId
3228469
displayName
MAP3K5 phosphorylates MKK3 and MKK6
edited
[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15
[InstanceEdit:4542306] Matthews, L, 2013-07-15
eventOf
[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens
followingEvent
[Reaction:R-HSA-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Homo sapiens
input
2 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[DefinedSet:R-HSA-167916] MAP2K3,MAP2K6 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:3228464] Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
[LiteratureReference:3228471] Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases
modified
[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name
MAP3K5 phosphorylates MKK3 and MKK6
orthologousEvent
[Reaction:R-CEL-3228469] MAP3K5 phosphorylates MKK3 and MKK6 - Caenorhabditis elegans
[Reaction:R-DME-3228469] MAP3K5 phosphorylates MKK3 and MKK6 - Drosophila melanogaster
[Reaction:R-GGA-3228469] MAP3K5 phosphorylates MKK3 and MKK6 - Gallus gallus
[Reaction:R-SSC-3228469] MAP3K5 phosphorylates MKK3 and MKK6 - Sus scrofa
[Reaction:R-BTA-3228469] MAP3K5 phosphorylates MKK3 and MKK6 - Bos taurus
[Reaction:R-CFA-3228469] MAP3K5 phosphorylates MKK3 and MKK6 - Canis familiaris
[Reaction:R-RNO-3228469] MAP3K5 phosphorylates MKK3 and MKK6 - Rattus norvegicus
[Reaction:R-MMU-3228469] MAP3K5 phosphorylates MKK3 and MKK6 - Mus musculus
output
2 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[DefinedSet:R-HSA-167984] p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol]
precedingEvent
[Reaction:R-HSA-3225851] ROS oxidize thioredoxin and activate MAP3K5 - Homo sapiens
releaseDate
2013-09-18
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-3228469
summation
[Summation:3296494] MAP3K5 (ASK1) phosphorylates and activates MAP2K3 (MKK3) and...
Referrals
(hasEvent)
[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence
(precedingEvent)
[Reaction:R-HSA-450296] Phosphorylated MKK3/MKK6 migrates to nucleus
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