Reactome | MAP3K5 phosphorylates MKK3 and MKK6

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MAP3K5 phosphorylates MKK3 and MKK6 Show undefined attributes

authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
catalystActivity	[CatalystActivity:3228467] protein serine/threonine kinase activity of MAP3K5 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3228463] Orlic-Milacic, M, 2013-03-25
dbId	3228469
displayName	MAP3K5 phosphorylates MKK3 and MKK6
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
eventOf	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens
followingEvent	[Reaction:R-HSA-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-HSA-167916] MAP2K3,MAP2K6 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3228464] Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways [LiteratureReference:3228471] Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	MAP3K5 phosphorylates MKK3 and MKK6
orthologousEvent	[Reaction:R-SCE-3228469] MAP3K5 phosphorylates MKK3 and MKK6 - Saccharomyces cerevisiae [Reaction:R-SPO-3228469] MAP3K5 phosphorylates MKK3 and MKK6 - Schizosaccharomyces pombe [Reaction:R-CEL-3228469] MAP3K5 phosphorylates MKK3 and MKK6 - Caenorhabditis elegans [Reaction:R-DME-3228469] MAP3K5 phosphorylates MKK3 and MKK6 - Drosophila melanogaster [Reaction:R-GGA-3228469] MAP3K5 phosphorylates MKK3 and MKK6 - Gallus gallus [Reaction:R-DRE-3228469] MAP3K5 phosphorylates MKK3 and MKK6 - Danio rerio [Reaction:R-SSC-3228469] MAP3K5 phosphorylates MKK3 and MKK6 - Sus scrofa [Reaction:R-BTA-3228469] MAP3K5 phosphorylates MKK3 and MKK6 - Bos taurus [Reaction:R-CFA-3228469] MAP3K5 phosphorylates MKK3 and MKK6 - Canis familiaris [Reaction:R-RNO-3228469] MAP3K5 phosphorylates MKK3 and MKK6 - Rattus norvegicus [Reaction:R-MMU-3228469] MAP3K5 phosphorylates MKK3 and MKK6 - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-167984] p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol]
precedingEvent	[Reaction:R-HSA-3225851] ROS oxidize thioredoxin and activate MAP3K5 - Homo sapiens
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3228469
summation	[Summation:3296494] MAP3K5 (ASK1) phosphorylates and activates MAP2K3 (MKK3) and...

Referrals

(hasEvent)	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence
(precedingEvent)	[Reaction:R-HSA-450296] Phosphorylated MKK3/MKK6 migrates to nucleus