PI3K alpha, beta, gamma convert PIP2 to PIP3

Stable Identifier
R-HSA-437162
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Class I Phosphoinositide 3-kinases (PI3Ks) are heterodimeric proteins, each having a catalytic subunit of 110-120 kDa and an associated regulatory subunit. PI3Ks alpha, beta and delta share a common regulatory p85 subunit, PI3K gamma has a p101 regulatory subunit. All the class I PI3Ks are able to phosphorylate PtdIns, PtdIns-4-P, or PtdIns-4,5-P2 (PIP2) on the free 3-position, and have a strong preference for PIP2.They are activated by receptor tyrosine kinases and by Ras and Rho family GTPases.

Literature References
PubMed ID Title Journal Year
7624799 Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

Stoyanov, B, Volinia, S, Hanck, T, Rubio, I, Loubtchenkov, M, Malek, D, Stoyanova, S, Vanhaesebroeck, B, Dhand, R, Nurnberg, B

Science 1995
8246984 Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85

Hu, P, Mondino, A, Skolnik, EY, Schlessinger, J

Mol Cell Biol 1993
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PI3K alpha, beta, gamma [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created