Reactome | PI3K alpha, beta, gamma convert PIP2 to PIP3

PI3K alpha, beta, gamma convert PIP2 to PIP3

Stable Identifier

R-HSA-437162

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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PI3K alpha, beta, gamma convert PIP2 to PIP3

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Class I Phosphoinositide 3-kinases (PI3Ks) are heterodimeric proteins, each having a catalytic subunit of 110-120 kDa and an associated regulatory subunit. PI3Ks alpha, beta and delta share a common regulatory p85 subunit, PI3K gamma has a p101 regulatory subunit. All the class I PI3Ks are able to phosphorylate PtdIns, PtdIns-4-P, or PtdIns-4,5-P2 (PIP2) on the free 3-position, and have a strong preference for PIP2.They are activated by receptor tyrosine kinases and by Ras and Rho family GTPases.

Literature References

PubMed ID	Title	Journal	Year
8246984	Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85 Schlessinger, J, Mondino, A, Hu, P, Skolnik, EY	Mol Cell Biol	1993
7624799	Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase Malek, D, Nurnberg, B, Dhand, R, Vanhaesebroeck, B, Volinia, S, Loubtchenkov, M, Stoyanov, B, Hanck, T, Stoyanova, S, Rubio, I	Science	1995