Class I Phosphoinositide 3-kinases (PI3Ks) are heterodimeric proteins, each having a catalytic subunit of 110-120 kDa and an associated regulatory subunit. PI3Ks alpha, beta and delta share a common regulatory p85 subunit, PI3K gamma has a p101 regulatory subunit. All the class I PI3Ks are able to phosphorylate PtdIns, PtdIns-4-P, or PtdIns-4,5-P2 (PIP2) on the free 3-position, and have a strong preference for PIP2.They are activated by receptor tyrosine kinases and by Ras and Rho family GTPases.
Schlessinger, J, Mondino, A, Hu, P, Skolnik, EY
Malek, D, Nurnberg, B, Dhand, R, Vanhaesebroeck, B, Volinia, S, Loubtchenkov, M, Stoyanov, B, Hanck, T, Stoyanova, S, Rubio, I
phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PI3K alpha, beta, gamma [cytosol]
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