Reactome | Activation of caspase-3

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Activation of caspase-3 Show undefined attributes

authored	[InstanceEdit:373757] Garapati, P V, 2008-07-16 14:42:16
catalystActivity	[CatalystActivity:418854] cysteine-type endopeptidase activity of DCC:DIP13alpha:Caspase-9 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:418857] Garapati, P V, 2009-04-27 09:26:20
dbId	418845
displayName	Activation of caspase-3
edited	[InstanceEdit:374705] Garapati, P V, 2008-07-30 10:24:23
eventOf	[Pathway:R-HSA-418889] Caspase activation via Dependence Receptors in the absence of ligand - Homo sapiens
followingEvent	[Reaction:R-HSA-418852] Caspase cleavage of UNC5B - Homo sapiens [Reaction:R-HSA-418846] Caspase cleavage of UNC5A - Homo sapiens [Reaction:R-HSA-201622] Caspase-mediated cleavage of gelsolin - Homo sapiens [Reaction:R-HSA-201629] Caspase-mediated cleavage of Tau - Homo sapiens [BlackBoxEvent:R-HSA-9647632] CASP3 cleaves GSDME - Homo sapiens [Reaction:R-HSA-211219] Translocation of caspase-3 to the nucleus - Homo sapiens [Reaction:R-HSA-202947] Caspase mediated cleavage of APC - Homo sapiens [Reaction:R-HSA-201603] Caspase-mediated cleavage of PKC theta - Homo sapiens [Reaction:R-HSA-202967] Caspase mediated cleavage of alpha-II-Fodrin - Homo sapiens [Reaction:R-HSA-202966] Caspase mediated cleavage of HIP-55 - Homo sapiens [Reaction:R-HSA-201608] Caspase-mediated cleavage of alpha adducin - Homo sapiens [Reaction:R-HSA-201628] Caspase-mediated cleavage of vimentin at DSVD (85) - Homo sapiens [Reaction:R-HSA-351877] Caspase-mediated cleavage of Desmoglein 2 - Homo sapiens [Reaction:R-HSA-202917] Caspase-mediated cleavage of Desmoglein 1 - Homo sapiens [Reaction:R-HSA-202939] Caspase-mediated cleavage of E-Cadherin - Homo sapiens [Reaction:R-HSA-202969] Caspase mediated cleavage of beta-catenin - Homo sapiens [Reaction:R-HSA-201631] Caspase-mediated cleavage of Desmoglein 3 - Homo sapiens [Reaction:R-HSA-201611] Caspase-mediated cleavage of Rock-1 - Homo sapiens [Reaction:R-HSA-212552] Caspase 3-mediated cleavage of PKC delta - Homo sapiens [Reaction:R-HSA-201640] Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha - Homo sapiens [Reaction:R-HSA-351849] Caspase-mediated cleavage of Etk - Homo sapiens [Reaction:R-HSA-202960] Caspase mediated cleavage of C-IAP1 - Homo sapiens [Reaction:R-HSA-201630] Caspase-mediated cleavage of Acinus - Homo sapiens [Reaction:R-HSA-350651] Caspase-mediated cleavage of MASK - Homo sapiens [Reaction:R-HSA-211651] Cleavage of PAK-2 at 212 - Homo sapiens [Reaction:R-HSA-201639] Caspase-mediated cleavage of GAS2 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-6804299] CASP3(1-277) dimer [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:373545] Mediation of the DCC apoptotic signal by DIP13 alpha [LiteratureReference:418749] Netrin-1 and its receptors in tumorigenesis
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	Activation of caspase-3
orthologousEvent	[Reaction:R-MMU-418845] Activation of caspase-3 - Mus musculus [Reaction:R-RNO-418845] Activation of caspase-3 - Rattus norvegicus [Reaction:R-CFA-418845] Activation of caspase-3 - Canis familiaris [Reaction:R-BTA-418845] Activation of caspase-3 - Bos taurus [Reaction:R-SSC-418845] Activation of caspase-3 - Sus scrofa
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-350870] Caspase-3 [cytosol]
precedingEvent	[Reaction:R-HSA-373700] Caspase-9 binds DCC:DIP13alpha complex - Homo sapiens
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:513006] Cooper, HM, 2010-02-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-418845
summation	[Summation:418751] The DCC-caspase activating complex activates caspase-3 throu...
updateTrackers	[UpdateTracker:9783789] Update Tracker - [Reaction:418845] Activation of caspase-3 - v55:[add_removeInput, add_removeOutput]

Referrals

(precedingEvent)	[Reaction:R-HSA-211219] Translocation of caspase-3 to the nucleus [Reaction:R-HSA-202947] Caspase mediated cleavage of APC [Reaction:R-HSA-201603] Caspase-mediated cleavage of PKC theta [Reaction:R-HSA-202967] Caspase mediated cleavage of alpha-II-Fodrin [Reaction:R-HSA-201639] Caspase-mediated cleavage of GAS2 [Reaction:R-HSA-202966] Caspase mediated cleavage of HIP-55 [Reaction:R-HSA-201622] Caspase-mediated cleavage of gelsolin [Reaction:R-HSA-201608] Caspase-mediated cleavage of alpha adducin [Reaction:R-HSA-201629] Caspase-mediated cleavage of Tau [Reaction:R-HSA-201628] Caspase-mediated cleavage of vimentin at DSVD (85) [Reaction:R-HSA-351877] Caspase-mediated cleavage of Desmoglein 2 [Reaction:R-HSA-202917] Caspase-mediated cleavage of Desmoglein 1 [Reaction:R-HSA-202939] Caspase-mediated cleavage of E-Cadherin [Reaction:R-HSA-202969] Caspase mediated cleavage of beta-catenin [Reaction:R-HSA-201631] Caspase-mediated cleavage of Desmoglein 3 [Reaction:R-HSA-201611] Caspase-mediated cleavage of Rock-1 [Reaction:R-HSA-212552] Caspase 3-mediated cleavage of PKC delta [Reaction:R-HSA-201640] Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha [Reaction:R-HSA-351849] Caspase-mediated cleavage of Etk [Reaction:R-HSA-202960] Caspase mediated cleavage of C-IAP1 [Reaction:R-HSA-201630] Caspase-mediated cleavage of Acinus [Reaction:R-HSA-350651] Caspase-mediated cleavage of MASK [Reaction:R-HSA-211651] Cleavage of PAK-2 at 212 [BlackBoxEvent:R-HSA-9647632] CASP3 cleaves GSDME [Reaction:R-HSA-418852] Caspase cleavage of UNC5B [Reaction:R-HSA-418846] Caspase cleavage of UNC5A
(hasEvent)	[Pathway:R-HSA-418889] Caspase activation via Dependence Receptors in the absence of ligand
(updatedInstance)	[UpdateTracker:9783789] Update Tracker - [Reaction:418845] Activation of caspase-3 - v55:[add_removeInput, add_removeOutput]

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