Activation of caspase-3

Stable Identifier
R-HSA-418845
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Activation of caspase-3
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The DCC-caspase activating complex activates caspase-3 through caspase-9.
Literature References
PubMed ID Title Journal Year
15573119 Netrin-1 and its receptors in tumorigenesis

Arakawa, H

Nat Rev Cancer 2004
12011067 Mediation of the DCC apoptotic signal by DIP13 alpha

Liu, J, Yao, F, Wu, R, Morgan, M, Thorburn, A, Finley RL, Jr, Chen, YQ

J Biol Chem 2002
Participants
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Output
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as an event of
Catalyst Activity

cysteine-type endopeptidase activity of DCC:DIP13alpha:Caspase-9 [plasma membrane]

Physical Entity
DCC:DIP13alpha:Caspase-9 [plasma membrane] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Activation of caspase-3 (Bos taurus)
Activation of caspase-3 (Canis familiaris)
Activation of caspase-3 (Mus musculus)
Activation of caspase-3 (Rattus norvegicus)
Activation of caspase-3 (Sus scrofa)
Authored
Garapati, P V  (2008-07-16)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2009-04-27)
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