Reactome | G alpha (s) signalling events

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G alpha (s) signalling events Show undefined attributes

authored	[InstanceEdit:418567] Jupe, S, 2009-04-23 16:22:25
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:418554] Jupe, S, 2009-04-23 15:30:05
crossReference	[DatabaseIdentifier:12819603] BioModels Database:BIOMD0000000842
dbId	418555
displayName	G alpha (s) signalling events
edited	[InstanceEdit:435382] Jupe, S, 2009-09-09
eventOf	[Pathway:R-HSA-388396] GPCR downstream signalling - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-744887] Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs - Homo sapiens [Reaction:R-HSA-379044] Liganded Gs-activating GPCR acts as a GEF for Gs - Homo sapiens [Reaction:R-HSA-744886] The Ligand:GPCR:Gs complex dissociates - Homo sapiens [Reaction:R-HSA-163617] G alpha (s) activates adenylate cyclase - Homo sapiens [Reaction:R-HSA-392129] Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate - Homo sapiens [Reaction:R-HSA-418553] cAMP degradation by Phosphodiesterases - Homo sapiens [Reaction:R-HSA-9708261] PDE4A hydrolyses cAMP to AMP - Homo sapiens [Reaction:R-HSA-9708275] PDE4A binds PDE4A inhibitors - Homo sapiens [Reaction:R-HSA-9629675] PDE3A hydrolyses cAMP to AMP - Homo sapiens [Reaction:R-HSA-9705507] PDE3B hydrolyses cAMP to AMP - Homo sapiens [Reaction:R-HSA-9629679] PDE3A inhibitors bind PDE3A - Homo sapiens [Reaction:R-HSA-164381] G alpha (s) auto-inactivates by hydrolysing GTP to GDP - Homo sapiens [Reaction:R-HSA-751013] Inactive G alpha (s) reassociates with G beta:gamma - Homo sapiens [Reaction:R-HSA-8851797] ADRB2 in ADRB2:GRK complex is phosphorylated - Homo sapiens [Reaction:R-HSA-8852167] ADRB2:Catecholamine binds ARRB1, ARRB2 - Homo sapiens [Reaction:R-HSA-8964278] G protein alpha (s):GTP binds SRC - Homo sapiens [Reaction:R-HSA-8964252] G alpha (s):GTP:SRC catalyzes SRC to p-Y419-SRC - Homo sapiens [Reaction:R-HSA-8964287] G alpha (s):GTP:SRC dissociates - Homo sapiens [Reaction:R-HSA-8982645] GRKs bind ADRB2:Catecholamine - Homo sapiens [Reaction:R-HSA-8982641] ADRB2:GRK complex dissociates to Phosphorylated ADRB2 - Homo sapiens [Pathway:R-HSA-9634597] GPER1 signaling - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-03-29
literatureReference	[LiteratureReference:425625] Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus
maxDepth	3
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	G alpha (s) signalling events
orthologousEvent	[Pathway:R-MMU-418555] G alpha (s) signalling events - Mus musculus [Pathway:R-RNO-418555] G alpha (s) signalling events - Rattus norvegicus [Pathway:R-CFA-418555] G alpha (s) signalling events - Canis familiaris [Pathway:R-SSC-418555] G alpha (s) signalling events - Sus scrofa [Pathway:R-DRE-418555] G alpha (s) signalling events - Danio rerio [Pathway:R-XTR-418555] G alpha (s) signalling events - Xenopus tropicalis [Pathway:R-GGA-418555] G alpha (s) signalling events - Gallus gallus [Pathway:R-DME-418555] G alpha (s) signalling events - Drosophila melanogaster [Pathway:R-CEL-418555] G alpha (s) signalling events - Caenorhabditis elegans [Pathway:R-DDI-418555] G alpha (s) signalling events - Dictyostelium discoideum [Pathway:R-SPO-418555] G alpha (s) signalling events - Schizosaccharomyces pombe [Pathway:R-SCE-418555] G alpha (s) signalling events - Saccharomyces cerevisiae [Pathway:R-PFA-418555] G alpha (s) signalling events - Plasmodium falciparum [Pathway:R-BTA-418555] G alpha (s) signalling events - Bos taurus
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
revised	[InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-418555
summation	[Summation:425617] The general function of the G alpha (s) subunit (Gs) is to a...
updateTrackers	[UpdateTracker:9783538] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v56:[addHasEvent] [UpdateTracker:9778404] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v68:[addHasEvent, updateContainedRLE] [UpdateTracker:9781558] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v60:[updateContainedRLE] [UpdateTracker:9790390] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v33:[addHasEvent, updateContainedRLE] [UpdateTracker:9776298] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v76:[add_removeHasEvent] [UpdateTracker:9774664] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v81:[addHasEvent] [UpdateTracker:9780495] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v63:[addHasEvent, modifyText] [UpdateTracker:9846789] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v84:[updateContainedRLE] [UpdateTracker:9778723] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v67:[addHasEvent, updateContainedRLE] [UpdateTracker:9777092] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v72:[addHasEvent] [UpdateTracker:9775429] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v79:[addHasEvent] [UpdateTracker:9777424] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v71:[removeHasEvent] [UpdateTracker:9780920] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v61:[addHasEvent, updateContainedRLE] [UpdateTracker:9791164] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v32:[add_removeHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9780745] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v62:[modifyText] [UpdateTracker:9776618] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v75:[addHasEvent, updateContainedRLE] [UpdateTracker:9864211] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v88:[updateContainedRLE, updateIndirectRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-388396] GPCR downstream signalling
(hasEncapsulatedEvent)	[Pathway:R-HSA-373076] Class A/1 (Rhodopsin-like receptors) [Pathway:R-HSA-373080] Class B/2 (Secretin family receptors)
(updatedInstance)	[UpdateTracker:9783538] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v56:[addHasEvent] [UpdateTracker:9778404] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v68:[addHasEvent, updateContainedRLE] [UpdateTracker:9781558] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v60:[updateContainedRLE] [UpdateTracker:9790390] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v33:[addHasEvent, updateContainedRLE] [UpdateTracker:9776298] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v76:[add_removeHasEvent] [UpdateTracker:9774664] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v81:[addHasEvent] [UpdateTracker:9780495] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v63:[addHasEvent, modifyText] [UpdateTracker:9846789] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v84:[updateContainedRLE] [UpdateTracker:9778723] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v67:[addHasEvent, updateContainedRLE] [UpdateTracker:9777092] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v72:[addHasEvent] [UpdateTracker:9775429] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v79:[addHasEvent] [UpdateTracker:9777424] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v71:[removeHasEvent] [UpdateTracker:9780920] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v61:[addHasEvent, updateContainedRLE] [UpdateTracker:9791164] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v32:[add_removeHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9780745] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v62:[modifyText] [UpdateTracker:9776618] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v75:[addHasEvent, updateContainedRLE] [UpdateTracker:9864211] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v88:[updateContainedRLE, updateIndirectRLE]

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