Reactome | Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate

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Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate Show undefined attributes

authored	[InstanceEdit:421900] Jupe, S, 2009-05-22 13:10:56
catalystActivity	[CatalystActivity:392125] adenylate cyclase activity of G alpha (s):GTP:Adenylate cyclase [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:392130] Jupe, S, 2009-02-27 11:22:10
crossReference	[DatabaseIdentifier:12667476] RHEA:15390
dbId	392129
displayName	Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate
edited	[InstanceEdit:435382] Jupe, S, 2009-09-09
eventOf	[Pathway:R-HSA-418555] G alpha (s) signalling events - Homo sapiens [Pathway:R-HSA-9660821] ADORA2B mediated anti-inflammatory cytokines production - Homo sapiens [Pathway:R-HSA-9634597] GPER1 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-9705507] PDE3B hydrolyses cAMP to AMP - Homo sapiens [Reaction:R-HSA-418553] cAMP degradation by Phosphodiesterases - Homo sapiens [Reaction:R-HSA-9708261] PDE4A hydrolyses cAMP to AMP - Homo sapiens [Reaction:R-HSA-9629675] PDE3A hydrolyses cAMP to AMP - Homo sapiens [Reaction:R-HSA-8951727] cAMP binds PKA tetramer - Homo sapiens
inferredFrom	[Reaction:R-CFA-421879] Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate - Canis familiaris
input	[SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:421881] Fractionation and characterization of a cyclic adenine ribonucleotide formed by tissue particles
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate
output	[SimpleEntity:R-ALL-30389] cAMP [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-HSA-392064] G alpha (z) inhibits adenylate cyclase - Homo sapiens [Reaction:R-HSA-163617] G alpha (s) activates adenylate cyclase - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-392138] Negative regulation by 'G-protein alpha (z):GTP:Adenylate cyclase [plasma membrane]' [NegativeRegulation:R-HSA-500806] Negative regulation by 'G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane]'
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
revised	[InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-392129
summation	[Summation:400657] The activation of adenylyl (adenylate) cyclase (AC) results ...
updateTrackers	[UpdateTracker:9778716] Update Tracker - [Reaction:392129] Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate - v67:[removeRegulator] [UpdateTracker:9778248] Update Tracker - [Reaction:392129] Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate - v68:[modifyText] [UpdateTracker:9790972] Update Tracker - [Reaction:392129] Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate - v32:[addRegulator] [UpdateTracker:9790520] Update Tracker - [Reaction:392129] Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate - v33:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9778716] Update Tracker - [Reaction:392129] Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate - v67:[removeRegulator] [UpdateTracker:9778248] Update Tracker - [Reaction:392129] Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate - v68:[modifyText] [UpdateTracker:9790972] Update Tracker - [Reaction:392129] Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate - v32:[addRegulator] [UpdateTracker:9790520] Update Tracker - [Reaction:392129] Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate - v33:[addRegulator]
(hasEvent)	[Pathway:R-HSA-9660821] ADORA2B mediated anti-inflammatory cytokines production [Pathway:R-HSA-418555] G alpha (s) signalling events [Pathway:R-HSA-9634597] GPER1 signaling [Pathway:R-HSA-418594] G alpha (i) signalling events [Pathway:R-HSA-418597] G alpha (z) signalling events
(precedingEvent)	[Reaction:R-HSA-9705507] PDE3B hydrolyses cAMP to AMP [Reaction:R-HSA-418553] cAMP degradation by Phosphodiesterases [Reaction:R-HSA-9708261] PDE4A hydrolyses cAMP to AMP [Reaction:R-HSA-9629675] PDE3A hydrolyses cAMP to AMP [Reaction:R-HSA-8951727] cAMP binds PKA tetramer
(inferredTo)	[Reaction:R-CFA-421879] Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate

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