Reactome | The general function of the G alpha (s) subunit (Gs) is to a...

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created	[InstanceEdit:425626] Jupe, S, 2009-06-05
dbId	425617
displayName	The general function of the G alpha (s) subunit (Gs) is to a...
literatureReference	[LiteratureReference:422307] Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS [LiteratureReference:8964277] Src tyrosine kinase is a novel direct effector of G proteins
modified	[InstanceEdit:9026067] Jupe, Steve, 2017-10-17
schemaClass	Summation
text	The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase (Tesmer et al. 1997), which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated. Another downstream effector of G alpha (s) is the protein tyrosine kinase c-Src (Ma et al. 2000).

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