Reactome | Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

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Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs Show undefined attributes

authored	[InstanceEdit:749459] Jupe, S, 2010-05-18
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:744888] Jupe, S, 2010-05-18
dbId	744887
displayName	Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
edited	[InstanceEdit:813668] Jupe, S, 2010-05-26
eventOf	[Pathway:R-HSA-418555] G alpha (s) signalling events - Homo sapiens
followingEvent	[Reaction:R-HSA-9660824] ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs - Homo sapiens [Reaction:R-HSA-379044] Liganded Gs-activating GPCR acts as a GEF for Gs - Homo sapiens
input	[Complex:R-HSA-391179] Heterotrimeric G-protein Gs (inactive) [plasma membrane] [DefinedSet:R-HSA-391181] Ligand:GPCR complexes that activate Gs [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:425625] Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
output	[Complex:R-HSA-744885] Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane]
precedingEvent	[Reaction:R-HSA-390674] ADRB1 bind ADR,NAd - Homo sapiens [Reaction:R-HSA-390835] DRD1,5 bind DA - Homo sapiens [Reaction:R-HSA-390909] HRH2 binds hist - Homo sapiens [Reaction:R-HSA-390931] 5-HT4, 6 and 7 receptors can bind serotonin - Homo sapiens [Reaction:R-HSA-391211] Trace amine-associated receptors can bind trace amines - Homo sapiens [Reaction:R-HSA-391378] Follicle-stimulating hormone receptor can bind FSH - Homo sapiens [Reaction:R-HSA-391377] Luteinizing hormone receptor can bind LH - Homo sapiens [Reaction:R-HSA-391942] IP receptor can bind prostacyclin - Homo sapiens [Reaction:R-HSA-391375] TSHR binds TSH/Thyrostimulin - Homo sapiens [Reaction:R-HSA-418925] ADORA2A,B bind Ade-Rib - Homo sapiens [Reaction:R-HSA-392263] AVP(20-28) binds AVPR2 - Homo sapiens [Reaction:R-HSA-420265] AMY1-3 bind IAPP(34-70) - Homo sapiens [Reaction:R-HSA-419843] CALCA(83-119) binds CALCR - Homo sapiens [Reaction:R-HSA-420127] CGRP receptor can bind calcitonin gene-related peptides - Homo sapiens [Reaction:R-HSA-420173] CRHR1,CRHR2-1 binds CRH,UCN - Homo sapiens [Reaction:R-HSA-420214] The adrenomedullin receptor can bind adrenomedullin and intermedin - Homo sapiens [Reaction:R-HSA-420274] GIP receptor binds gastric inhibitory peptide - Homo sapiens [Reaction:R-HSA-163625] Glucagon binds to Glucagon receptor - Homo sapiens [Reaction:R-HSA-420123] Glucagon-like receptor 2 binds GLP2 - Homo sapiens [Reaction:R-HSA-381612] GLP1R binds GLP1 - Homo sapiens [Reaction:R-HSA-420243] GHRH receptor binds GHRH - Homo sapiens [Reaction:R-HSA-420131] The PACAP receptor binds PACAP - Homo sapiens [Reaction:R-HSA-420233] VIP receptors bind VIP - Homo sapiens [Reaction:R-HSA-420489] Parathyroid hormone receptor can bind parathyroid hormone - Homo sapiens [Reaction:R-HSA-420202] Secretin receptor binds secretin - Homo sapiens [Reaction:R-HSA-444620] Neuropeptide S receptor binds neuropeptide S - Homo sapiens [Reaction:R-HSA-444838] Relaxin receptor 1 binds relaxin 2 and 3 - Homo sapiens [Reaction:R-HSA-444879] Relaxin receptor 2 binds relaxin 2 and INSL3 - Homo sapiens [Reaction:R-HSA-444654] G-protein coupled bile acid receptor binds lithocholic acid - Homo sapiens [Reaction:R-HSA-444572] Zinc is an agonist of GPR39 - Homo sapiens
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:782850] D'Eustachio, P, 2010-05-21
revised	[InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-744887
summation	[Summation:391178] The role of the guanine nucleotide-binding protein G alpha-s...

Referrals

(hasEvent)	[Pathway:R-HSA-418555] G alpha (s) signalling events
(precedingEvent)	[Reaction:R-HSA-9660824] ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs [Reaction:R-HSA-379044] Liganded Gs-activating GPCR acts as a GEF for Gs

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