Reactome | ADRB2 in ADRB2:GRK complex is phosphorylated

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ADRB2 in ADRB2:GRK complex is phosphorylated Show undefined attributes

authored	[InstanceEdit:8851799] Jupe, Steve, 2016-01-11
catalystActivity	[CatalystActivity:8852025] beta-adrenergic receptor kinase activity of ADRB2:Catecholamine:GRK [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:8851799] Jupe, Steve, 2016-01-11
dbId	8851797
displayName	ADRB2 in ADRB2:GRK complex is phosphorylated
eventOf	[Pathway:R-HSA-418555] G alpha (s) signalling events - Homo sapiens
followingEvent	[Reaction:R-HSA-8982641] ADRB2:GRK complex dissociates to Phosphorylated ADRB2 - Homo sapiens
input	[Complex:R-HSA-8982633] ADRB2:Catecholamine:GRK [plasma membrane] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8851801] Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor [LiteratureReference:8852024] Phosphorylation and desensitization of human m2 muscarinic cholinergic receptors by two isoforms of the beta-adrenergic receptor kinase [LiteratureReference:8852210] Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration [LiteratureReference:8852155] G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	ADRB2 in ADRB2:GRK complex is phosphorylated
orthologousEvent	[Reaction:R-BTA-8851797] ADRB2 in ADRB2:GRK complex is phosphorylated - Bos taurus [Reaction:R-DME-8851797] ADRB2 in ADRB2:GRK complex is phosphorylated - Drosophila melanogaster [Reaction:R-GGA-8851797] ADRB2 in ADRB2:GRK complex is phosphorylated - Gallus gallus [Reaction:R-XTR-8851797] ADRB2 in ADRB2:GRK complex is phosphorylated - Xenopus tropicalis [Reaction:R-DRE-8851797] ADRB2 in ADRB2:GRK complex is phosphorylated - Danio rerio [Reaction:R-SSC-8851797] ADRB2 in ADRB2:GRK complex is phosphorylated - Sus scrofa [Reaction:R-CFA-8851797] ADRB2 in ADRB2:GRK complex is phosphorylated - Canis familiaris [Reaction:R-RNO-8851797] ADRB2 in ADRB2:GRK complex is phosphorylated - Rattus norvegicus [Reaction:R-MMU-8851797] ADRB2 in ADRB2:GRK complex is phosphorylated - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-8982648] pS-ADRB2:Catecholamine:GRK [plasma membrane]
precedingEvent	[Reaction:R-HSA-8982645] GRKs bind ADRB2:Catecholamine - Homo sapiens
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8852258] Jassal, Bijay, 2016-01-15
revised	[InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8851797
summation	[Summation:8851790] G protein-coupled receptor kinase 2 (ADRBK1, GRK2, beta-ARK)...
updateTrackers	[UpdateTracker:9781064] Update Tracker - [Reaction:8851797] ADRB2 in ADRB2:GRK complex is phosphorylated - v61:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9781064] Update Tracker - [Reaction:8851797] ADRB2 in ADRB2:GRK complex is phosphorylated - v61:[add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-418555] G alpha (s) signalling events
(precedingEvent)	[Reaction:R-HSA-8982641] ADRB2:GRK complex dissociates to Phosphorylated ADRB2

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