Reactome | G alpha (s) activates adenylate cyclase

Schema > Reaction > Entries

G alpha (s) activates adenylate cyclase Show undefined attributes

authored	[InstanceEdit:392829] Jupe, S, 2009-03-09 10:38:40
catalystActivity	[CatalystActivity:9857009] adenylate cyclase activator activity of G alpha (s):GTP [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:163620] Gopinathrao, G, 2005-05-03 20:30:53
dbId	163617
displayName	G alpha (s) activates adenylate cyclase
edited	[InstanceEdit:432201] May, B, 2009-08-11
eventOf	[Pathway:R-HSA-163359] Glucagon signaling in metabolic regulation - Homo sapiens [Pathway:R-HSA-9660821] ADORA2B mediated anti-inflammatory cytokines production - Homo sapiens [Pathway:R-HSA-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells - Homo sapiens
followingEvent	[Reaction:R-HSA-164377] Activated Adenylate cyclase catalyses cAMP synthesis - Homo sapiens [Reaction:R-HSA-392129] Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate - Homo sapiens
input	[Complex:R-HSA-170665] Adenylate cyclase (Mg2+ cofactor) [plasma membrane] [Complex:R-HSA-164358] G alpha (s):GTP [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:422307] Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS [LiteratureReference:8982636] Mechanism of Galpha i-mediated inhibition of type V adenylyl cyclase
maxDepth	1
modified	[InstanceEdit:9866199] May, Bruce, 2024-03-23
name	G alpha (s) activates adenylate cyclase
orthologousEvent	[Reaction:R-HSA-9712187] GNAL:GTP (G alpha-olf) binds ADCY3 - Homo sapiens
output	[Complex:R-HSA-163622] G alpha (s):GTP:Adenylate cyclase [plasma membrane]
precedingEvent	[Reaction:R-HSA-392874] Dissociation of the Prostacyclin receptor:Gs complex - Homo sapiens [Reaction:R-HSA-422320] Heterotrimeric G(s) complex dissociates - Homo sapiens [Reaction:R-HSA-744886] The Ligand:GPCR:Gs complex dissociates - Homo sapiens [Reaction:R-HSA-825631] Glucagon:GCGR mediates GTP-GDP exchange - Homo sapiens [Reaction:R-HSA-9660819] ADORA2B:Ade-Rib:GsGTP dissociates - Homo sapiens [Reaction:R-HSA-9861293] ADM:CALCRL:RAMP2:G-alpha(s):GTP:G-beta:G-gamma dissociates - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:425201] Akkerman, JW, 2009-06-03 [InstanceEdit:9860028] D'Eustachio, Peter, 2024-01-29 [InstanceEdit:9860030] D'Eustachio, Peter, 2024-01-29
revised	[InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-163617
summation	[Summation:178800] G(s)-alpha:GTP binds to inactive adenylate cyclase, causing ...
updateTrackers	[UpdateTracker:9781345] Update Tracker - [Reaction:163617] G alpha (s) activates adenylate cyclase - v61:[addLiteratureReference] [UpdateTracker:9864023] Update Tracker - [Reaction:163617] G alpha (s) activates adenylate cyclase - v88:[addCatalystActivity] [UpdateTracker:9790384] Update Tracker - [Reaction:163617] G alpha (s) activates adenylate cyclase - v33:[add_removeInput] [UpdateTracker:9791464] Update Tracker - [Reaction:163617] G alpha (s) activates adenylate cyclase - v30:[addLiteratureReference] [UpdateTracker:9791637] Update Tracker - [Reaction:163617] G alpha (s) activates adenylate cyclase - v28:[add_removeInput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9781345] Update Tracker - [Reaction:163617] G alpha (s) activates adenylate cyclase - v61:[addLiteratureReference] [UpdateTracker:9864023] Update Tracker - [Reaction:163617] G alpha (s) activates adenylate cyclase - v88:[addCatalystActivity] [UpdateTracker:9790384] Update Tracker - [Reaction:163617] G alpha (s) activates adenylate cyclase - v33:[add_removeInput] [UpdateTracker:9791464] Update Tracker - [Reaction:163617] G alpha (s) activates adenylate cyclase - v30:[addLiteratureReference] [UpdateTracker:9791637] Update Tracker - [Reaction:163617] G alpha (s) activates adenylate cyclase - v28:[add_removeInput, modifyText]
(hasEvent)	[Pathway:R-HSA-163359] Glucagon signaling in metabolic regulation [Pathway:R-HSA-9660821] ADORA2B mediated anti-inflammatory cytokines production [Pathway:R-HSA-432040] Vasopressin regulates renal water homeostasis via Aquaporins [Pathway:R-HSA-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells [Pathway:R-HSA-418555] G alpha (s) signalling events [Pathway:R-HSA-9634597] GPER1 signaling
(precedingEvent)	[Reaction:R-HSA-164377] Activated Adenylate cyclase catalyses cAMP synthesis [Reaction:R-HSA-392129] Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate

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