Reactome | G alpha (s) signalling events

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G alpha (s) signalling events Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10993901
displayName	G alpha (s) signalling events
eventOf	[Pathway:R-CEL-388396] GPCR downstream signalling - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-CEL-379044] Liganded Gs-activating GPCR acts as a GEF for Gs - Caenorhabditis elegans [Reaction:R-CEL-418553] cAMP degradation by Phosphodiesterases - Caenorhabditis elegans [Reaction:R-CEL-9708261] PDE4A hydrolyses cAMP to AMP - Caenorhabditis elegans [Reaction:R-CEL-9708275] PDE4A binds PDE4A inhibitors - Caenorhabditis elegans [Reaction:R-CEL-9629675] PDE3A hydrolyses cAMP to AMP - Caenorhabditis elegans [Reaction:R-CEL-9705507] PDE3B hydrolyses cAMP to AMP - Caenorhabditis elegans [Reaction:R-CEL-9629679] PDE3A inhibitors bind PDE3A - Caenorhabditis elegans [Pathway:R-CEL-9634597] GPER1 signaling - Caenorhabditis elegans
inferredFrom	[Pathway:R-HSA-418555] G alpha (s) signalling events - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	G alpha (s) signalling events
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-418555
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEncapsulatedEvent)	[Pathway:R-CEL-373080] Class B/2 (Secretin family receptors) [Pathway:R-CEL-373076] Class A/1 (Rhodopsin-like receptors)
(hasEvent)	[Pathway:R-CEL-388396] GPCR downstream signalling
(inferredTo)	[Pathway:R-HSA-418555] G alpha (s) signalling events

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