Reactome | G alpha (q) signalling events

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G alpha (q) signalling events Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10329137
displayName	G alpha (q) signalling events
eventOf	[Pathway:R-CFA-388396] GPCR downstream signalling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-CFA-749448] Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq - Canis familiaris [Reaction:R-CFA-379048] Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 - Canis familiaris [Reaction:R-CFA-749452] The Ligand:GPCR:Gq complex dissociates - Canis familiaris [Reaction:R-CFA-416516] GRK2 sequesters activated Gq - Canis familiaris [Reaction:R-CFA-400586] G alpha (q) binds to Trio family RhoGEFs - Canis familiaris [Reaction:R-CFA-416358] G alpha (q) inhibits PI3K alpha - Canis familiaris [Reaction:R-CFA-418582] G alpha (q) auto-inactivates by hydrolysing GTP to GDP - Canis familiaris [Reaction:R-CFA-750993] Inactive G alpha (q) reassociates with G beta:gamma - Canis familiaris [Pathway:R-CFA-114508] Effects of PIP2 hydrolysis - Canis familiaris [Reaction:R-CFA-8964280] Active Gq binds BTK - Canis familiaris [Reaction:R-CFA-8964284] BTK in active Gq-BTK complex is activated - Canis familiaris [Reaction:R-CFA-8964340] Gq-BTK complex dissociates to Active BTK and Gq - Canis familiaris [Reaction:R-CFA-8982017] Active G alpha (q) binds RGS proteins - Canis familiaris [Reaction:R-CFA-8982025] G alpha (q) in G (q):RGS complex is inactivated - Canis familiaris [Reaction:R-CFA-8982026] G alpha (q):RGS dissociates to inactive G alpha (q) - Canis familiaris [Reaction:R-CFA-114688] PLC-beta hydrolyses PIP2 to DAG and IP3 - Canis familiaris [Pathway:R-CFA-881907] Gastrin-CREB signalling pathway via PKC and MAPK - Canis familiaris
inferredFrom	[Pathway:R-HSA-416476] G alpha (q) signalling events - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	4
name	G alpha (q) signalling events
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-416476
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEncapsulatedEvent)	[Pathway:R-CFA-373080] Class B/2 (Secretin family receptors) [Pathway:R-CFA-420499] Class C/3 (Metabotropic glutamate/pheromone receptors) [Pathway:R-CFA-373076] Class A/1 (Rhodopsin-like receptors) [Pathway:R-CFA-881907] Gastrin-CREB signalling pathway via PKC and MAPK
(hasEvent)	[Pathway:R-CFA-388396] GPCR downstream signalling
(inferredTo)	[Pathway:R-HSA-416476] G alpha (q) signalling events

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