Reactome | BTK in active Gq-BTK complex is activated

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BTK in active Gq-BTK complex is activated Show undefined attributes

authored	[InstanceEdit:9014287] Varusai, Thawfeek, 2017-07-27
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8964250] Varusai, Thawfeek, 2017-02-16
dbId	8964284
displayName	BTK in active Gq-BTK complex is activated
edited	[InstanceEdit:9014287] Varusai, Thawfeek, 2017-07-27
eventOf	[Pathway:R-HSA-416476] G alpha (q) signalling events - Homo sapiens
followingEvent	[Reaction:R-HSA-8964340] Gq-BTK complex dissociates to Active BTK and Gq - Homo sapiens
input	[Complex:R-HSA-8964296] Active Gq:BTK [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8964321] Direct stimulation of Bruton's tyrosine kinase by G(q)-protein alpha-subunit [LiteratureReference:8964338] Identification of the binding site for Gqalpha on its effector Bruton's tyrosine kinase [LiteratureReference:9006764] Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: intramolecular contact versus asymmetric homodimerization
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	BTK in active Gq-BTK complex is activated
orthologousEvent	[Reaction:R-DME-8964284] BTK in active Gq-BTK complex is activated - Drosophila melanogaster [Reaction:R-GGA-8964284] BTK in active Gq-BTK complex is activated - Gallus gallus [Reaction:R-XTR-8964284] BTK in active Gq-BTK complex is activated - Xenopus tropicalis [Reaction:R-DRE-8964284] BTK in active Gq-BTK complex is activated - Danio rerio [Reaction:R-SSC-8964284] BTK in active Gq-BTK complex is activated - Sus scrofa [Reaction:R-BTA-8964284] BTK in active Gq-BTK complex is activated - Bos taurus [Reaction:R-CFA-8964284] BTK in active Gq-BTK complex is activated - Canis familiaris [Reaction:R-RNO-8964284] BTK in active Gq-BTK complex is activated - Rattus norvegicus [Reaction:R-MMU-8964284] BTK in active Gq-BTK complex is activated - Mus musculus
output	[Complex:R-HSA-8964303] Active Gq:Active BTK [plasma membrane]
precedingEvent	[Reaction:R-HSA-8964280] Active Gq binds BTK - Homo sapiens
releaseDate	2018-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9618881] Huang, Xin-Yun, 2018-09-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8964284
summation	[Summation:8964245] G-Protein Coupled Receptors (GPCR) sense extracellular signa...

Referrals

(precedingEvent)	[Reaction:R-HSA-8964340] Gq-BTK complex dissociates to Active BTK and Gq
(hasEvent)	[Pathway:R-HSA-416476] G alpha (q) signalling events