Reactome | Ca2+ pathway

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Ca2+ pathway Show undefined attributes

authored	[InstanceEdit:4086401] Rothfels, K, 2013-08-07
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:4086397] Rothfels, K, 2013-08-07
dbId	4086398
displayName	Ca2+ pathway
edited	[InstanceEdit:4663813] Matthews, L, 2013-10-07
eventOf	[Pathway:R-HSA-3858494] Beta-catenin independent WNT signaling - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:20146] Wnt signaling pathway, calcium modulating pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-3965446] WNT5A and WNT11 bind FZD receptors to initiate Ca2+ signaling - Homo sapiens [Reaction:R-HSA-3965441] FZD recruits trimeric G-proteins - Homo sapiens [Reaction:R-HSA-3965444] WNT:FZD complex promotes G-protein nucleotide exchange - Homo sapiens [Reaction:R-HSA-3965447] G-protein subunits dissociate from WNT:FZD complex - Homo sapiens [Reaction:R-HSA-398040] Gbeta:gamma activation of PLC beta - Homo sapiens [Reaction:R-HSA-398193] PLC beta-mediated PIP2 hydrolysis - Homo sapiens [Reaction:R-HSA-4332390] Translocation and activation of PKC alpha in response to WNT signaling - Homo sapiens [Reaction:R-HSA-169680] IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel - Homo sapiens [Reaction:R-HSA-2730872] Activation of Calcineurin - Homo sapiens [Reaction:R-HSA-4551451] Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling - Homo sapiens [BlackBoxEvent:R-HSA-4551465] Translocation of NFATC1:CaN:CaM to nucleus - Homo sapiens [Reaction:R-HSA-4420052] Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT - Homo sapiens [Reaction:R-HSA-4086393] G alpha t2 binds and activates PDE6 - Homo sapiens [Reaction:R-HSA-4086392] PDE6 hydrolyses cGMP to GMP - Homo sapiens [Reaction:R-HSA-4332359] Active calmodulin binds CAMK2 - Homo sapiens [Reaction:R-HSA-4551453] PRKG is activated by binding to high levels of cGMP in the absence of WNT signaling - Homo sapiens [Reaction:R-HSA-4332363] Autophosphorylation and activation of CAMK2 - Homo sapiens [Reaction:R-HSA-4332358] Dissociation of CaM and CAMK2 autophosphorylation - Homo sapiens [Reaction:R-HSA-4332356] CAMK2 binds MAP3K7 - Homo sapiens [BlackBoxEvent:R-HSA-4332388] Activation of MAP3K7 in response to WNT - Homo sapiens [Reaction:R-HSA-4411402] Activation of NLK - Homo sapiens [BlackBoxEvent:R-HSA-4411373] NLK translocates to nucleus - Homo sapiens [Reaction:R-HSA-4411383] NLK phosphorylates TCF/LEF - Homo sapiens [BlackBoxEvent:R-HSA-4518575] miR-92b binds 3'UTR of NLK mRNA - Homo sapiens [BlackBoxEvent:R-HSA-4518585] NLK mRNA translation controlled by miR-92b - Homo sapiens [Reaction:R-HSA-8944362] TCF/LEF:CTNNB1 bind canonical WNT target promoters - Homo sapiens [BlackBoxEvent:R-HSA-4411365] Transcription of canonical WNT targets is negatively regulated by NLK-dependent phosphorylation of TCF/LEF - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-09-09
literatureReference	[LiteratureReference:3965329] Wnt/Ca2+ signaling pathway: a brief overview [LiteratureReference:3247719] Wnt and calcium signaling: beta-catenin-independent pathways [LiteratureReference:4546337] Noncanonical Wnt signaling in vertebrate development, stem cells, and diseases
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Ca2+ pathway
orthologousEvent	[Pathway:R-MMU-4086398] Ca2+ pathway - Mus musculus [Pathway:R-RNO-4086398] Ca2+ pathway - Rattus norvegicus [Pathway:R-CFA-4086398] Ca2+ pathway - Canis familiaris [Pathway:R-BTA-4086398] Ca2+ pathway - Bos taurus [Pathway:R-SSC-4086398] Ca2+ pathway - Sus scrofa [Pathway:R-DRE-4086398] Ca2+ pathway - Danio rerio [Pathway:R-XTR-4086398] Ca2+ pathway - Xenopus tropicalis [Pathway:R-GGA-4086398] Ca2+ pathway - Gallus gallus [Pathway:R-DME-4086398] Ca2+ pathway - Drosophila melanogaster [Pathway:R-CEL-4086398] Ca2+ pathway - Caenorhabditis elegans [Pathway:R-DDI-4086398] Ca2+ pathway - Dictyostelium discoideum [Pathway:R-SPO-4086398] Ca2+ pathway - Schizosaccharomyces pombe [Pathway:R-SCE-4086398] Ca2+ pathway - Saccharomyces cerevisiae
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-4086398
summation	[Summation:4551457] A number of so called non-canonical WNT ligands have been sh...
updateTrackers	[UpdateTracker:9864115] Update Tracker - [Pathway:4086398] Ca2+ pathway - v88:[updateContainedRLE] [UpdateTracker:9786832] Update Tracker - [Pathway:4086398] Ca2+ pathway - v48:[updateContainedRLE] [UpdateTracker:9786240] Update Tracker - [Pathway:4086398] Ca2+ pathway - v50:[updateContainedRLE] [UpdateTracker:9782609] Update Tracker - [Pathway:4086398] Ca2+ pathway - v59:[addHasEvent, updateContainedRLE] [UpdateTracker:9777531] Update Tracker - [Pathway:4086398] Ca2+ pathway - v70:[updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-3858494] Beta-catenin independent WNT signaling

(updatedInstance)

[UpdateTracker:9864115] Update Tracker - [Pathway:4086398] Ca2+ pathway - v88:[updateContainedRLE]
[UpdateTracker:9786832] Update Tracker - [Pathway:4086398] Ca2+ pathway - v48:[updateContainedRLE]
[UpdateTracker:9786240] Update Tracker - [Pathway:4086398] Ca2+ pathway - v50:[updateContainedRLE]
[UpdateTracker:9782609] Update Tracker - [Pathway:4086398] Ca2+ pathway - v59:[addHasEvent, updateContainedRLE]
[UpdateTracker:9777531] Update Tracker - [Pathway:4086398] Ca2+ pathway - v70:[updateContainedRLE]

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