Reactome | G-protein subunits dissociate from WNT:FZD complex

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G-protein subunits dissociate from WNT:FZD complex Show undefined attributes

authored	[InstanceEdit:3858502] Rothfels, K, 2013-07-09
category	dissociation
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:3965448] Rothfels, K, 2013-07-23
dbId	3965447
displayName	G-protein subunits dissociate from WNT:FZD complex
edited	[InstanceEdit:4663813] Matthews, L, 2013-10-07
eventOf	[Pathway:R-HSA-4086398] Ca2+ pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-4086393] G alpha t2 binds and activates PDE6 - Homo sapiens [Reaction:R-HSA-8964241] G beta-gamma complex and PIP3 recruit BTK to membrane - Homo sapiens [Reaction:R-HSA-398040] Gbeta:gamma activation of PLC beta - Homo sapiens [Reaction:R-HSA-8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex - Homo sapiens
input	[Complex:R-HSA-3965394] WNT5A/11:FZD:G-protein (alpha o/t2) active [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4539765] Frizzleds: new members of the superfamily of G-protein-coupled receptors [LiteratureReference:4546341] Wnt-frizzled signaling to G-protein-coupled effectors [LiteratureReference:508598] G protein betagamma subunits: central mediators of G protein-coupled receptor signaling [LiteratureReference:4086381] Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	G-protein subunits dissociate from WNT:FZD complex
orthologousEvent	[Reaction:R-GGA-3965447] G-protein subunits dissociate from WNT:FZD complex - Gallus gallus [Reaction:R-BTA-3965447] G-protein subunits dissociate from WNT:FZD complex - Bos taurus [Reaction:R-CFA-3965447] G-protein subunits dissociate from WNT:FZD complex - Canis familiaris [Reaction:R-MMU-3965447] G-protein subunits dissociate from WNT:FZD complex - Mus musculus
output	[DefinedSet:R-HSA-3965383] G-protein alpha (o/t2) [plasma membrane] [Complex:R-HSA-167434] G-protein beta-gamma complex [plasma membrane] [Complex:R-HSA-3965390] WNT5A/11:FZD [plasma membrane]
precedingEvent	[Reaction:R-HSA-3965444] WNT:FZD complex promotes G-protein nucleotide exchange - Homo sapiens
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3965447
summation	[Summation:4551470] After nucleotide exchange, the G-protein alpha subunit disso...

Referrals

(precedingEvent)	[Reaction:R-HSA-8964241] G beta-gamma complex and PIP3 recruit BTK to membrane [Reaction:R-HSA-8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex [Reaction:R-HSA-4086393] G alpha t2 binds and activates PDE6 [Reaction:R-HSA-398040] Gbeta:gamma activation of PLC beta [NegativePrecedingEvent:9864363] Futile Cycle: G-protein subunits dissociate from WNT:FZD complex
(hasEvent)	[Pathway:R-HSA-4086398] Ca2+ pathway