Reactome | Translocation and activation of PKC alpha in response to WNT signaling

Schema > Reaction > Entries

Translocation and activation of PKC alpha in response to WNT signaling Show undefined attributes

authored	[InstanceEdit:4420051] Rothfels, K, 2013-08-29
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:4332391] Rothfels, K, 2013-08-16
dbId	4332390
displayName	Translocation and activation of PKC alpha in response to WNT signaling
edited	[InstanceEdit:4663813] Matthews, L, 2013-10-07
eventOf	[Pathway:R-HSA-4086398] Ca2+ pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-2730872] Activation of Calcineurin - Homo sapiens
inferredFrom	[Reaction:R-XLA-4332392] translocation of Xenopus prkca to plasma membrane - Xenopus laevis
input	3 × [SimpleEntity:R-ALL-74016] Ca2+ [cytosol] [SimpleEntity:R-ALL-114519] DAG [plasma membrane] [EntityWithAccessionedSequence:R-HSA-4332337] p-T497,T638,S657-PRKCA [cytosol] [SimpleEntity:R-ALL-33625] PS [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:4332322] Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner [LiteratureReference:3247705] The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape [LiteratureReference:3965321] The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition [LiteratureReference:4518576] Wnt5A activates the calpain-mediated cleavage of filamin A [LiteratureReference:3965336] Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma
maxDepth	1
modified	[InstanceEdit:9864375] Orlic-Milacic, Marija, 2024-03-07
name	Translocation and activation of PKC alpha in response to WNT signaling
output	[Complex:R-HSA-4332385] activated PKC alpha [plasma membrane]
precedingEvent	[Reaction:R-HSA-398193] PLC beta-mediated PIP2 hydrolysis - Homo sapiens [Reaction:R-HSA-4420052] Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT - Homo sapiens
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4332390
summation	[Summation:4518587] Ectopic expression of Xwnt5a or Rfz2 in Xenopus embryos resu...

Referrals

(hasEvent)	[Pathway:R-HSA-4086398] Ca2+ pathway
(precedingEvent)	[Reaction:R-HSA-2730872] Activation of Calcineurin
(inferredTo)	[Reaction:R-XLA-4332392] translocation of Xenopus prkca to plasma membrane

Cite Us!