Reactome | WNT:FZD complex promotes G-protein nucleotide exchange

Schema > Reaction > Entries

WNT:FZD complex promotes G-protein nucleotide exchange Show undefined attributes

authored	[InstanceEdit:3858502] Rothfels, K, 2013-07-09
catalystActivity	[CatalystActivity:3965443] guanyl-nucleotide exchange factor activity of WNT5A/11:FZD:G-protein (alpha o/t2) inactive [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:3965442] Rothfels, K, 2013-07-23
dbId	3965444
displayName	WNT:FZD complex promotes G-protein nucleotide exchange
edited	[InstanceEdit:4663813] Matthews, L, 2013-10-07
eventOf	[Pathway:R-HSA-4086398] Ca2+ pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-3965447] G-protein subunits dissociate from WNT:FZD complex - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-3965393] WNT5A/11:FZD:G-protein (alpha o/t2) inactive [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4539765] Frizzleds: new members of the superfamily of G-protein-coupled receptors
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	WNT:FZD complex promotes G-protein nucleotide exchange
orthologousEvent	[Reaction:R-CEL-3965444] WNT:FZD complex promotes G-protein nucleotide exchange - Caenorhabditis elegans [Reaction:R-GGA-3965444] WNT:FZD complex promotes G-protein nucleotide exchange - Gallus gallus [Reaction:R-XTR-3965444] WNT:FZD complex promotes G-protein nucleotide exchange - Xenopus tropicalis [Reaction:R-SSC-3965444] WNT:FZD complex promotes G-protein nucleotide exchange - Sus scrofa [Reaction:R-BTA-3965444] WNT:FZD complex promotes G-protein nucleotide exchange - Bos taurus [Reaction:R-CFA-3965444] WNT:FZD complex promotes G-protein nucleotide exchange - Canis familiaris [Reaction:R-RNO-3965444] WNT:FZD complex promotes G-protein nucleotide exchange - Rattus norvegicus [Reaction:R-MMU-3965444] WNT:FZD complex promotes G-protein nucleotide exchange - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-3965394] WNT5A/11:FZD:G-protein (alpha o/t2) active [plasma membrane]
precedingEvent	[Reaction:R-HSA-3965441] FZD recruits trimeric G-proteins - Homo sapiens
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3965444
summation	[Summation:4551468] After binding the FZD receptor, the G-protein alpha subunit ...

Referrals

(hasEvent)	[Pathway:R-HSA-4086398] Ca2+ pathway
(precedingEvent)	[Reaction:R-HSA-3965447] G-protein subunits dissociate from WNT:FZD complex

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