Reactome | Translocation of NFATC1:CaN:CaM to nucleus

Schema > BlackBoxEvent > Entries

Translocation of NFATC1:CaN:CaM to nucleus Show undefined attributes

authored	[InstanceEdit:4551565] Rothfels, K, 2013-09-13
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:4551450] Rothfels, K, 2013-09-13
dbId	4551465
displayName	Translocation of NFATC1:CaN:CaM to nucleus
edited	[InstanceEdit:4663813] Matthews, L, 2013-10-07
eventOf	[Pathway:R-HSA-4086398] Ca2+ pathway - Homo sapiens
input	[Complex:R-HSA-4551448] NFATC1:CaN:CaM [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2025907] Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity [LiteratureReference:2685136] Transcriptional regulation by calcium, calcineurin, and NFAT [LiteratureReference:3965320] The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos [LiteratureReference:3965328] Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1alpha signaling in human mammary epithelial cells
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Translocation of NFATC1:CaN:CaM to nucleus
orthologousEvent	[BlackBoxEvent:R-CEL-4551465] Translocation of NFATC1:CaN:CaM to nucleus - Caenorhabditis elegans [BlackBoxEvent:R-DME-4551465] Translocation of NFATC1:CaN:CaM to nucleus - Drosophila melanogaster [BlackBoxEvent:R-GGA-4551465] Translocation of NFATC1:CaN:CaM to nucleus - Gallus gallus [BlackBoxEvent:R-DRE-4551465] Translocation of NFATC1:CaN:CaM to nucleus - Danio rerio [BlackBoxEvent:R-SSC-4551465] Translocation of NFATC1:CaN:CaM to nucleus - Sus scrofa [BlackBoxEvent:R-BTA-4551465] Translocation of NFATC1:CaN:CaM to nucleus - Bos taurus [BlackBoxEvent:R-CFA-4551465] Translocation of NFATC1:CaN:CaM to nucleus - Canis familiaris [BlackBoxEvent:R-RNO-4551465] Translocation of NFATC1:CaN:CaM to nucleus - Rattus norvegicus [BlackBoxEvent:R-MMU-4551465] Translocation of NFATC1:CaN:CaM to nucleus - Mus musculus
output	[Complex:R-HSA-4551463] NFATC1:CaN:CaM [nucleoplasm]
precedingEvent	[Reaction:R-HSA-4551451] Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling - Homo sapiens
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-4551465
summation	[Summation:4551464] Dephosphorylated NFAT-calcineurin (CaN) complex translocates...

Referrals

(hasEvent)

[Pathway:R-HSA-4086398] Ca2+ pathway